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• Clinical Article •
A resting-state fMRI study of spontaneous brain activity in persons dependent on both nicotine and alcohol
WANG Lingfei  ZHANG Yong  NIU Xiaoyu  GAO Xinyu  ZHANG Mengzhe  WANG Weijian  CHENG Jingliang 

Cite this article as: WANG L F, ZHANG Y, NIU X Y, et al. A resting-state fMRI study of spontaneous brain activity in persons dependent on both nicotine and alcohol[J]. Chin J Magn Reson Imaging, 2023, 14(11): 1-5, 24. DOI:10.12015/issn.1674-8034.2023.11.001.


[Abstract] Objective To investigate the effects of smoking and drinking on brain spontaneous activity and the neurobiological mechanism of comorbidity between smoking and drinking.Materials and Methods Based on the amplitude of low-frequency fluctuation (ALFF) method, a 2×2 factorial design was employed to investigate the effects of alcohol on ALFF in individuals categorized into four groups: alcohol-consuming smokers (n=35) and alcohol-consuming non-smokers (n=27), as well as non-alcohol-consuming smokers (n=21) and non-alcohol-consuming non-smokers (n=25). Resting-state functional magnetic resonance imaging (fMRI) scans were performed to acquire brain data, and ALFF values were calculated for each group. Subsequently, an analysis of variance (ANOVA) was conducted to assess the differences in ALFF values among the four groups. To further explore specific group differences, post hoc tests (Bonferroni correction) were conducted based on the ANOVA results. The study aims to gain insights into the impact of alcohol consumption on ALFF in the context of nicotine dependence, contributing to a deeper understanding of neural activity and its modulation in addiction.Results Compared with healthy controls, the smoking group had higher ALFF values in the bilateral precuneus and right cuneus (t=3.212, P=0.001), while the drinking group had higher ALFF values in the left cerebellar hemisphere (t=3.422, P=0.001), with P＜0.005 for voxel levels and P＜0.05 for mass levels, based on GRF correction. Smoking and alcohol consumption jointly affected brain activity in the left posterior cerebellar lobe, but with opposite effects. ALFF values in the left posterior cerebellar lobe were negatively correlated with smoking age, pack-years and drinking dependence scale scores (n=35; r=-0.367, P=0.025; r=-0.267, P=0.033; r=-0.293, P=0.026).Conclusions Smoking and alcohol consumption both affect spontaneous brain activity, and their interaction occurs in the left posterior cerebellar lobe. Smoking and drinking produce a novel antagonistic interaction. This suggests that we need to control for alcohol consumption as a variable when studying spontaneous brain activity in smokers.
[Keywords] low frequency oscillation amplitude；nicotine addiction；alcohol consumption；interaction effect；resting-state functional magnetic resonance imaging

WANG Lingfei   ZHANG Yong*   NIU Xiaoyu   GAO Xinyu   ZHANG Mengzhe   WANG Weijian   CHENG Jingliang  

Department of Magnetic Resonance, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450002, China

Corresponding author: ZHANG Y, E-mail: zzuzhangyong2013@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Key Research and Development and Promotion (Science and Technology) Project of Henan Province (No. 212102310712).
Received  2023-05-05
Accepted  2023-10-31
DOI: 10.12015/issn.1674-8034.2023.11.001
Cite this article as: WANG L F, ZHANG Y, NIU X Y, et al. A resting-state fMRI study of spontaneous brain activity in persons dependent on both nicotine and alcohol[J]. Chin J Magn Reson Imaging, 2023, 14(11): 1-5, 24. DOI:10.12015/issn.1674-8034.2023.11.001.

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