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• Clinical Article •
Application of surface-based morphometry and voxel-based morphometry in "MRI negative" frontal lobe epilepsy of children and adolescents
RAN Chunyan  ZHANG Tijiang  XU Gaoqiang  ZENG Zhen  LI Wenfu 

Cite this article as: RAN C Y, ZHANG T J, XU G Q, et al. Application of surface-based morphometry and voxel-based morphometry in "MRI negative" frontal lobe epilepsy of children and adolescents[J]. Chin J Magn Reson Imaging, 2023, 14(11): 6-11. DOI:10.12015/issn.1674-8034.2023.11.002.


[Abstract] Objective Surface-based morphometry (SBM) and voxel-based morphometry (VBM) were used to measure the whole brain morphology of frontal lobe epilepsy in children and adolescents with negative MRI. The morphological characteristics of brain microstructure changes in children and adolescents with epilepsy were discussed. The correlation between the brain regions with the change of brain microstructure and the course of disease and intelligence quotient (IQ) was analyzed.Materials and Methods Children and adolescents with epilepsy were collected from the Department of Neurology and Pediatrics of our hospital. The diagnosis of children with epilepsy should meet the diagnostic criteria established by the International League Against Epilepsy (ILAE) in 2017. Patients with frontal lobe epilepsy were selected as case group according to the medical history, electroencephalogram analysis and clinical symptoms of the children. Healthy children were recruited as control group. Clinical information of the case group and control group should be recorded in detail. Two groups were tested with MRI to obtain high-resolution 3D-T1WI structural image data and T2-fluid attenuated inversion recovery (T2-FLAIR) data. The case group underwent an intelligence test using the China-Wechsler Intelligence Scale for Children within 3 days of examination. SBM and VBM used FreeSurfer software and VBM software. SPSS 23.0 was used to analyze the correlation between brain areas and disease duration and IQ in children with MRI negative frontal lobe epilepsy, and compare the similarities and differences of abnormal brain areas obtained by SBM and VBM.Results There was no significant difference in gender, age and education between the two groups (P＞0.05), compared with the control group, the results of SBM showed abnormal brain areas in the case group: the frontal pole, superior frontal gyrus, posterior central gyrus, middle frontal gyrus, inferior frontal gyrus and bilateral superior temporal gyrus in the left cerebral cortex decreased (P＜0.05), the precuneus and precuneus and bilateral superior temporal gyrus in the superior, middle and inferior gyrus of the left and right cerebral cortex decreased reduced (P＜0.05); the results of VBM analysis showed reduced gray matter volume in the left inferior temporal gyrus, right screen nucleus and middle frontal gyrus and bilateral posterior central gyrus in children and adolescents with epilepsy (P＜0.05), there was no significant correlation between abnormal brain areas and disease course and IQ (P＜0.05).Conclusions SBM and VBM analysis methods can both detect brain regions with abnormal brain morphology in children and adolescents with frontal lobe epilepsy, and SBM can extract more abnormal brain regions than VBM analysis; morphological changes of middle frontal gyrus and posterior central gyrus were observed in both analysis methods; the abnormal changes in the brain regions of children and adolescents with frontal lobe epilepsy mainly involve the frontal lobe and peripheral brain regions.
[Keywords] frontal lobe epilepsy；surface-based morphometry；voxel-based morphometry；Freesurfer；magnetic resonance imaging；child；adolescent

RAN Chunyan   ZHANG Tijiang*   XU Gaoqiang   ZENG Zhen   LI Wenfu  

Department of Imaging, Affiliated Hospital of Zunyi Medical University, Guizhou Medical Image Center, Zunyi 563000, China

Corresponding author: ZHANG T J, E-mail: tijzhang@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81960312); Project of Intelligent Medical Imaging Engineering Research Center of Guizhou University (No. Qian Jiao Ji [2023] 038); Zunyi Science and Technology Plan Project (No. Zun Shi Ke He HZ Word [2021] 48).
Received  2023-05-31
Accepted  2023-11-03
DOI: 10.12015/issn.1674-8034.2023.11.002
Cite this article as: RAN C Y, ZHANG T J, XU G Q, et al. Application of surface-based morphometry and voxel-based morphometry in "MRI negative" frontal lobe epilepsy of children and adolescents[J]. Chin J Magn Reson Imaging, 2023, 14(11): 6-11. DOI:10.12015/issn.1674-8034.2023.11.002.

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