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• Clinical Article •
Application of MR amide proton transfer imaging and apparent diffusion coefficient in preoperative pathological grade assessment of bladder cancer
XU Xinghua  CHANG Lingyu  WU Guangtai  CHENG Lianhua  LI Shuyi  WANG Fang  WANG Qing 

Cite this article as: XU X H, CHANG L Y, WU G T, et al. Application of MR amide proton transfer imaging and apparent diffusion coefficient in preoperative pathological grade assessment of bladder cancer[J]. Chin J Magn Reson Imaging, 2023, 14(11): 97-102. DOI:10.12015/issn.1674-8034.2023.11.016.


[Abstract] Objective To study the feasibility of amide proton transfer (APT) imaging and apparent diffusion coefficient (ADC) in the preoperative histological grade assessment of bladder cancer.Materials and Methods The imaging data of 54 cases of bladder cancer confirmed by surgery and pathology were retrospectively analyzed, all patients underwent magnetic resonance examination before surgery, and the scanning sequences included APT and diffusion-weighted imaging (DWI) functional sequences except for conventional sequences. APT and ADC values of tumors were measured by two experienced radiologists independently. An independent samples t-test or Mann-Whitney U-test was used to compare the differences in each parameter between different grades of tumors. The receiver operating characteristic (ROC) curves and DeLong test were used to evaluate the efficiency of APT, ADC and combined parameters.Results The APT values for low-grade bladder cancer (1.42%±0.75%) were significantly lower than high-grade bladder cancer (2.99%±1.07%), with statistically significant differences (P＜0.01); and the ADC values for low-grade bladder cancer were significantly higher [(1.44±0.27)×10-3 mm2/s] than high-grade bladder cancer [(1.17±0.37)×10-3 mm2/s], with statistically significant differences (P=0.01). The ROC curves showed that the area under the curve (AUC) of APT, ADC and the combined indicators for differentiating low-grade and high-grade bladder cancers were 0.80, 0.76, 0.94, and the AUC of combined parameters was significantly higher than that in APT or ADC (all P＜0.05).Conclusions APT and ADC can be used as indicators to predict the preoperative histological grades of bladder cancer, and the combination of APT and ADC can significantly improve the diagnostic efficacy.
[Keywords] bladder cancer；magnetic resonance imaging；amide proton transfer imaging；apparent diffusion coefficient；functional magnetic resonance imaging；histologic grades

XU Xinghua   CHANG Lingyu   WU Guangtai   CHENG Lianhua   LI Shuyi   WANG Fang   WANG Qing*  

Department of Radiology, Qilu Hospital of Shandong University, Jinan 250012, China

Corresponding author: WANG Q, E-mail: wangqing663@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of Shandong Province (No. ZR2019MH049).
Received  2023-04-27
Accepted  2023-08-09
DOI: 10.12015/issn.1674-8034.2023.11.016
Cite this article as: XU X H, CHANG L Y, WU G T, et al. Application of MR amide proton transfer imaging and apparent diffusion coefficient in preoperative pathological grade assessment of bladder cancer[J]. Chin J Magn Reson Imaging, 2023, 14(11): 97-102. DOI:10.12015/issn.1674-8034.2023.11.016.

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