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• Clinical Article •
A preliminary study of quantitative parameters derived from synthetic MRI for predicting the lymphovascular space invasion status in cervical squamous cell carcinoma
GUO Limei  WANG Jun  WU Wenqi  ZHANG Yujing  ZHANG Runmei  NIU Jinliang 

Cite this article as: GUO L M, WANG J, WU W Q, et al. A preliminary study of quantitative parameters derived from synthetic MRI for predicting the lymphovascular space invasion status in cervical squamous cell carcinoma[J]. Chin J Magn Reson Imaging, 2023, 14(11): 103-107, 120. DOI:10.12015/issn.1674-8034.2023.11.017.


[Abstract] Objective To investigate the feasibility of synthetic MRI [longitudinal relaxation time (T1), transverse relaxation time (T2), and proton density (PD)] for the prediction of the lymphovascular space invasion (LVSI) status in cervical squamous cell carcinoma (CSCC).Materials and methods Patients who first went to the Second Hospital of Shanxi Medical University for suspected cervical cancer from May 2020 to November 2022 were prospectively collected. All patients underwent preoperative routine MRI scan, sagittal synthetic MRI to obtain the T1, T2, and PD values of the tumor. According to the LVSI status confirmed by postoperative pathological diagnosis, the subjects were divided into positive and negative LVSI groups. Use independent sample t-test or U-test to compare T1, T2 and PD values between the two groups. The receiver operating characteristic (ROC) curve was applied to evaluate the diagnostic efficacy of each parameter in predicting the LVSI status of CSCC.Results A total of 80 patients with operatively pathology confirmed CSCC were included in the study, including positive LVSI (n=51) and negative LVSI (n=29). There were significant differences in T1 value [(1191.60±101.17) ms vs. (1316.58±107.42) ms] and T2 value [(80.72±5.62) ms vs. (89.79±7.43) ms], all P＜0.001. In term of distinguishing LVSI positive from LVSI negative, the area under the curve (AUC) for T1 and T2 values were 0.798 and 0.850, respectively. A combination of T1 and T2 values showed a higher diagnostic performance (AUC=0.881), although there was no significant difference between T1, T2 and the AUC value of the combined parameter model (P＞0.05) by DeLong test.Conclusion The quantitative parameters from synthetic MRI have potential for evaluating the LVSI status of CSCC and to help to optimize therapeutic strategies.
[Keywords] cervical neoplasms；cervical squamous cell carcinoma；synthetic magnetic resonance imaging；lymphovascular space invasion；predict

GUO Limei   WANG Jun   WU Wenqi   ZHANG Yujing   ZHANG Runmei   NIU Jinliang*  

Department of Radiology, Second Hospital of Shanxi Medical School, Taiyuan 030001, China

Corresponding author: NIU J L, E-mail: sxlscjy@163.com

Conflicts of interest   None.

Received  2023-03-27
Accepted  2023-10-27
DOI: 10.12015/issn.1674-8034.2023.11.017
Cite this article as: GUO L M, WANG J, WU W Q, et al. A preliminary study of quantitative parameters derived from synthetic MRI for predicting the lymphovascular space invasion status in cervical squamous cell carcinoma[J]. Chin J Magn Reson Imaging, 2023, 14(11): 103-107, 120. DOI:10.12015/issn.1674-8034.2023.11.017.

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