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• Technical Article •
Investigating the feasibility of reducing the usage of Gd-DTPA in MRI brain enhancement by improving the quality of acquired image through DL-Recon
LIANG Dan  ZHANG Mo  MA Suwen  LU Jie 

Cite this article as: LIANG D, ZHANG M, MA S W, et al. Investigating the feasibility of reducing the usage of Gd-DTPA in MRI brain enhancement by improving the quality of acquired image through DL-Recon[J]. Chin J Magn Reson Imaging, 2023, 14(11): 136-141. DOI:10.12015/issn.1674-8034.2023.11.022.


[Abstract] Objective To investigate the feasibility of reducing the effect of Gd-diethylenetriamine pentametric acid (Gd-DTPA) dose on image quality in MRI brain enhancement by improving the acquired image through deep learning reconstruction (DL-Recon) algorithm.Materials and Methods The patients were divided equally into two groups, the normal dose group and the reduced dose group, and the corresponding T1WI were acquired using conventional reconstruction methods and DL-Recon techniques for the two groups. The region of interest was determined for signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) analysis under double-blind conditions by two associate chief, and subjective and objective evaluation of image quality, artefacts, homogeneity and enhancement effects were performed, with the subjective evaluation method based on the LIKERT guideline. The objective evaluation was performed by calculating the SNR of the image background, the superior frontal gyrus (SFG), the subarachnoid space (SAS) and the red nucleus (RN), respectively. The SNR was evaluated for image contrast.Results The image quality obtained using DL-Recon was significantly increased (SNRSFG increased by 48.9%, CNRSFG increased by 91.5%) compared with that of conventional reconstruction method after injection of normal dose, and there was no significant correlation with the injection dose of Gd-DTPA. The artifacts and overall quality scores of DL-Recon were significantly higher than those of conventional images (P＜0.05). There was no significant difference in the enhancement effect of DL-Recon image + reduced dose group compared with that of conventional reconstruction in the normal injection dose group (P＞0.05).Conclusions MRI DL-Recon algorithm has the ability to reduce the injection amount of Gd-DTPA on the premise of ensuring image quality.
[Keywords] intracranial tumours；Gd-diethylenetriamine pentametric acid；lower dose；deep learning reconstruction gadolinium；magnetic resonance imaging

LIANG Dan1   ZHANG Mo1, 2   MA Suwen1   LU Jie1, 2*  

1 Department of Radiology and Nucler Medicine, Xuanwu Hospital Capital Medical University, Beijing 100053, China

2 Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing 100053, China

Corresponding author: LU J, E-mail: imaginglu@hotmail.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Huizhi Talent Project-Support Plan-Leading Talent (No. HZ2021ZCLJ005).
Received  2022-10-21
Accepted  2023-09-06
DOI: 10.12015/issn.1674-8034.2023.11.022
Cite this article as: LIANG D, ZHANG M, MA S W, et al. Investigating the feasibility of reducing the usage of Gd-DTPA in MRI brain enhancement by improving the quality of acquired image through DL-Recon[J]. Chin J Magn Reson Imaging, 2023, 14(11): 136-141. DOI:10.12015/issn.1674-8034.2023.11.022.

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