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• Clinical Article •
Study of gray matter volume changes in cerebellar subregions of type 2 diabetes and its correlation with insulin resistance
ZHANG Huiyan  SHEN Guo  YANG Chen  TAN Jian  TIAN Jing  LI Zhoule  HUANG Gang  ZHAO Lianping 

Cite this article as: ZHANG H Y, SHEN G, YANG C, et al. Study of gray matter volume changes in cerebellar subregions of type 2 diabetes and its correlation with insulin resistance[J]. Chin J Magn Reson Imaging, 2023, 14(12): 1-5. DOI:10.12015/issn.1674-8034.2023.12.001.


[Abstract] Objective A voxel-based morphometry (VBM) was used to investigate the abnormal patterns of gray matter volume of cerebellar subregions of type 2 diabetes mellitus (T2DM) patients using spatially unbiased infratentorial template for fine subregion segmentation of the cerebellum.Materials and Methods Seventy-five patients with T2DM and 53 healthy controls (HCs) were recruited, and collected cranial MRI image data, clinical data, and cognitive-psychological scales from all subjects. Differences in gray matter volume in cerebellar subregions between T2DM and HCs were compared by independent samples t test, and Pearson or Spearman correlation analysis was performed with clinical data and scores of cognitive-psychological scales in differential cerebellar subregions.Results Compared with HCs, T2DM patients had lower Montreal Cognitive Assessment scores and higher 24-item Hamilton Depression Scale and Hamilton Anxiety Scale scores (P＜0.001). Reduced gray matter volume in the right cerebellar Crus Ⅰ and bilateral cerebellar lobules Ⅰ-Ⅴ/Ⅰ-Ⅳ subregions (voxel level P＜0.001, cluster size＞100). The body mass index was positively correlated with right lobules Ⅰ-Ⅴ (r=0.265, P=0.022), left lobules Ⅰ-Ⅳ (r=0.323, P=0.005) subregions gray matter volume, and gray matter volume in right Crus Ⅰ subregion was negatively correlated with fasting insulin levels (r=-0.263, P=0.023) and updated homeostasis model assessment insulin resistance index (r=-0.327, P=0.004).Conclusions Patients with T2DM are at risk for mild cognitive impairment and depression and anxiety, and reduced gray matter volume of right Crus Ⅰ may be associated with insulin resistance.
[Keywords] type 2 diabetes mellitus；magnetic resonance imaging；cerebellum；gray matter volume；insulin resistance

ZHANG Huiyan1, 3   SHEN Guo1, 3   YANG Chen2   TAN Jian2   TIAN Jing3   LI Zhoule2   HUANG Gang3   ZHAO Lianping1, 3*  

1 School of Clinical Medicine, Ningxia Medical University, Yinchuan 750000, China

2 The First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital), Lanzhou 730000, China

3 Department of Radiology, Gansu Provincial Hospital, Lanzhou 730000, China

Corresponding author: ZHAO L P, E-mail: lianping_zhao007@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81901724); Research Fund of Gansu Provincial Hospital (No. 22GSSYD-75).
Received  2023-07-06
Accepted  2023-12-02
DOI: 10.12015/issn.1674-8034.2023.12.001
Cite this article as: ZHANG H Y, SHEN G, YANG C, et al. Study of gray matter volume changes in cerebellar subregions of type 2 diabetes and its correlation with insulin resistance[J]. Chin J Magn Reson Imaging, 2023, 14(12): 1-5. DOI:10.12015/issn.1674-8034.2023.12.001.

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