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• Clinical Article •
Clinical diagnosis value of multi-b value diffusion weighted imaging in Alzheimer's disease
QIU Yanhua  CHEN Qiuyan  SHI Liwei  ZHENG Tianxiu  ZHANG Deyong  WEI Dingtai 

Cite this article as: QIU Y H, CHEN Q Y, SHI L W, et al. Clinical diagnosis value of multi-b value diffusion weighted imaging in Alzheimer's disease[J]. Chin J Magn Reson Imaging, 2023, 14(12): 6-14. DOI:10.12015/issn.1674-8034.2023.12.002.


[Abstract] Objective To explore the value of multi-b diffusion-weighted imaging (MB-DWI) in the clinical diagnosis of Alzheimer's disease (AD), in order to assist clinical diagnosis and treatment in the early stage of AD.Materials and Methods A total of 68 subjects were enrolled in the study, including three subject populations: 24 subjects with AD, 29 subjects with cognitive impairment (MCI), and 15 normal controls (NC) with no cognitive complaints. Statistical differences in apparent diffusion coefficient (ADC), intravoxel incoherent motion-diffusion coefficient (IVIM-D), intravoxel incoherent motion-perfusion fraction (IVIM-f), aquaporin-apparent diffusion coefficient (AQP-ADC) were compared using one-way ANOVA or Cruskal-Wallis test, and further comparison between groups was performed using Bonferroni method. In addition, the correlation between clinical cognitive score and the above indexes was further analyzed.Results In the analysis of AQP-ADC and IVIM-D, the differences between the MCI group and the NC group were mainly in the frontal cortex (right P=0.046; left P=0.016), hippocampus (right P=0.020; left P=0.022), thalamus (right P=0.022; left P=0.001) and left temporal white matter (P=0.049). The results showed that compared with the NC group, the AD group showed more regional differences in the progression of AD. In addition, AQP-ADC and IVIM-D had superiority in detecting MCI and AD compared with conventional ADC when receiver operating characteristic curves (ROC) were used to analyze the diagnostic performance of MB-DWI related indexes.Conclusions Compared with conventional DWI, MB-DWI has significant advantages in AD diagnosis, especially in providing additional information at the MCI stage. MB-DWI may be another early biomarker and measure of disease progression for AD-related pathophysiological changes.
[Keywords] Alzheimer's disease；mild cognitive impairment；magnetic resonance imaging；functional magnetic resonance imaging；multi-b value diffusion weighted imaging

QIU Yanhua1   CHEN Qiuyan2, 3   SHI Liwei2, 3   ZHENG Tianxiu2, 3   ZHANG Deyong2, 3   WEI Dingtai2, 3*  

1 Department of Imaging, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China

2 Department of Imaging, Ningde Hospital Affiliated to Ningde Normal University, Ningde 352100, China

3 Functional and Molecular Imaging Laboratory for Cerebral Vascular Diseases, Ningde Hospital Affiliated to Ningde Normal University, Ningde 352100, China

Corresponding author: WEI D T, E-mail: wdtai83@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Natural Science Foundation of Fujian Province (No. 2021J011158); Special Project of Innovation Team of Ningde Normal University in 2020.
Received  2023-04-06
Accepted  2023-11-07
DOI: 10.12015/issn.1674-8034.2023.12.002
Cite this article as: QIU Y H, CHEN Q Y, SHI L W, et al. Clinical diagnosis value of multi-b value diffusion weighted imaging in Alzheimer's disease[J]. Chin J Magn Reson Imaging, 2023, 14(12): 6-14. DOI:10.12015/issn.1674-8034.2023.12.002.

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