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• Clinical Article •
Application of DCE-MRI combined with IVIM quantitative parameters in the treatment evaluation of brucellosis spondylitis
ZHAO Pengfei  HE Hongbing  WANG Haohua  LI Yupu  ZHANG Zhaojing  QIAO Pengfei 

Cite this article as: ZHAO P F, HE H B, WANG H H, et al. Application of DCE-MRI combined with IVIM quantitative parameters in the treatment evaluation of brucellosis spondylitis[J]. Chin J Magn Reson Imaging, 2023, 14(12): 72-77. DOI:10.12015/issn.1674-8034.2023.12.012.


[Abstract] Objective To evaluate the therapeutic effect of Brucella spondylitis in the acute phase, we used dynamic contrast-enhanced MRI (DCE-MRI) combined with intravoxel incoherent motion (IVIM) quantitative parameters to observe the changes of various quantitative parameters during the disease treatment process and to select the best evaluation quantitative parameters.Materials and Methods We prospectively enrolled 30 patients with acute phase of first confirmed Brucella spondylitis. What's more, all patients underwent routine MRI, DCE-MRI, and IVIM scans 3 months after initial diagnosis and treatment. Measurement of volume transport constant (Ktrans), extracellular volume fraction (Ve), rate constant (Kep), slow diffusion coefficient (D), fast diffusion coefficient (D*), and perfusion fraction (f) in the most significant area of the lesion (most significantly enhanced area) in a controlled study; We used SPSS 25.0 statistical software for data analysis, and all indicators showed a non-normal distribution, represented by the median ± interquartile interval (M±Q). Wilcoxon rank sum test was used for statistical analysis of various quantitative parameters.Results Ktrans values were (0.53±0.02), (0.22±0.01) min-1, Ve values were 0.45±0.01, 0.48±0.03, Kep values were (1.18±0.04), (0.46±0.04) min-1, D values were (0.53±0.01)×10-3, (0.91±0.01) ×10-3 mm2/s, D* values were (6.01±0.26)×10-3, (5.81±0.21)×10-3 mm2/s, and f values were 0.32±0.04, 0.29±0.03, respectively, after the first diagnosis and treatment of Brucella spondylitis; The differences in Ktrans, Kep, and D values within the group were statistically significant (Z were -4.784, -4.783, and -4.786, respectively, with P＜0.01).Conclusions The first application of DCE-MRI combined with IVIM quantitative parameters to evaluate the treatment effect of Brucella spondylitis in the acute phase provides a more scientific and objective evaluation of the microenvironmental changes from a microscopic perspective, providing a new basis for guiding clinical medication.
[Keywords] Brucellosis spondylitis；acute phase；magnetic resonance imaging；dynamic contrast-enhanced；intravoxel incoherent motion；treatment evaluation

ZHAO Pengfei1   HE Hongbing2   WANG Haohua1   LI Yupu1   ZHANG Zhaojing1   QIAO Pengfei1*  

1 Imaging Diagnosis Department, Inner Mongolia Medical University Affiliated Hospital, Hohhot 010050, China

2 Traditional Chinese Medicine, Mongolian Medicine, Brucella Disease Department, Hohhot Second Hospital, Hohhot 010031, China

Corresponding author: QIAO P F, E-mail: qpfff@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Inner Mongolia Autonomous Region Natural Science Foundation Project (No. 2023QN08044); Inner Mongolia Autonomous Region Health Science and Technology Plan Project (No. 202202177); Inner Mongolia Medical University Youth Cultivation Project (No.YKD2021QN032).
Received  2023-09-06
Accepted  2023-12-07
DOI: 10.12015/issn.1674-8034.2023.12.012
Cite this article as: ZHAO P F, HE H B, WANG H H, et al. Application of DCE-MRI combined with IVIM quantitative parameters in the treatment evaluation of brucellosis spondylitis[J]. Chin J Magn Reson Imaging, 2023, 14(12): 72-77. DOI:10.12015/issn.1674-8034.2023.12.012.

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