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Study of ReHo and fALFF in patients with obstructive sleep apnea hypopnea syndrome
WANG Qin  XIONG Yanxi  ZHANG Zili  AO Feng  LI Sheng  LI Yanhong  CHEN Guangbin 

Cite this article as: WANG Q, XIONG Y X, ZHANG Z L, et al. Study of ReHo and fALFF in patients with obstructive sleep apnea hypopnea syndrome[J]. Chin J Magn Reson Imaging, 2023, 14(12): 98-102. DOI:10.12015/issn.1674-8034.2023.12.016.


[Abstract] Objective To investigate the brain regions with abnormal neural activity in the patients with obstructive sleep apnea hypopnea syndrome (OSAHS), using regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuation (fALFF) of the rest-state functional magnetic resonance imaging (rs-fMRI) technique.Materials and Methods A total of 30 male patients with OSAHS who were initially diagnosed and untreated by polysomnography (PSG) in the Department of Respiratory of Shiyan Renmin Hospital were collected, and 30 volunteers with normal sleep, similar age and education level monitored by PSG during the same period were selected as the normal control (NC) group. Rs-fMRI examination was performed to obtain blood oxygen level dependent (BOLD) signals. ReHo, fALFF are used to compare the OSAHS group with the NC group to find out the brain regions with significant differences.Results Compared with the NC group, the OSAHS group has significant differences between ReHo and fALFF (P＜0.001). The brain regions with increased ReHo value included left pons (t=3.94, P＜0.001), left anterior cerebellar lobe (t=4.68, P＜0.001) and right anterior cerebellar lobe (t=4.94, P＜0.001). The brain region with decreased ReHo value is none. The brain regions with increased fALFF value are left posterior lobe of the cerebellum (t=6.20, P＜0.001), left superior temporal gyrus (t=5.49, P＜0.001), and left fusiform gyrus (t=4.35, P＜0.001). The brain region with decreased fALFF value is left paracentral lobule (t=-4.12, P＜0.001).Conclusions In patients with OSAHS, the ReHo value and the fALFF value in multiple brain regions were changed. The ReHo value of some brain regions in OSAHS patients increased, and the brain regions that fALFF value changed were mostly concentrated in the left cerebral hemisphere.
[Keywords] obstructive sleep apnea；brain network；functional magnetic resonance imaging；magnetic resonance imaging；regional homogeneity；fractional amplitude of low-frequency fluctuation

WANG Qin1, 2   XIONG Yanxi1, 2*   ZHANG Zili1, 2   AO Feng1, 2   LI Sheng1, 2   LI Yanhong3   CHEN Guangbin1, 2  

1 Department of Radiography Center, Shiyan Renmin Hospital (Affiliated People's Hospital of Hubei University of Medicine), Shiyan 442099, China

2 Institute of Radiology, Shiyan Renmin Hospital (Affiliated People's Hospital of Hubei University of Medicine), Shiyan 442099, China

3 Department of Respiratory Medicine, Shiyan Renmin Hospital (Affiliated People's Hospital of Hubei University of Medicine), Shiyan 442099, China

Corresponding author: XIONG Y X, E-mail: hixiongyanxi@163.com

Conflicts of interest   None.

Received  2021-07-29
Accepted  2023-12-02
DOI: 10.12015/issn.1674-8034.2023.12.016
Cite this article as: WANG Q, XIONG Y X, ZHANG Z L, et al. Study of ReHo and fALFF in patients with obstructive sleep apnea hypopnea syndrome[J]. Chin J Magn Reson Imaging, 2023, 14(12): 98-102. DOI:10.12015/issn.1674-8034.2023.12.016.

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