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Advances in MRI study of structural and functional changes in the limbic system of Parkinson's disease with depression
QU Mingrui  GAO Bingbing  MIAO Yanwei 

Cite this article as: QU M R, GAO B B, MIAO Y W. Advances in MRI study of structural and functional changes in the limbic system of Parkinson's disease with depression[J]. Chin J Magn Reson Imaging, 2023, 14(12): 127-131. DOI:10.12015/issn.1674-8034.2023.12.022.


[Abstract] Depression is one of the most common non-motor symptoms of Parkinson's disease (PD). It usually appears in the early stage of the disease, seriously affecting the quality of life and increasing the burden of the disease. Neuroimaging has found a wide range of structural and functional abnormalities in the limbic system, especially the orbitofrontal lobe, anterior cingulate gyrus, amygdala and hippocampus are closely related to the pathophysiology of PD with depression (DPD). Therefore, taking the limbic system as a starting point, this paper reviews the MRI studies related to the changes of brain structure and function in DPD patients, in order to provide new ideas for future research.
[Keywords] Parkinson's disease；depression；limbic system；magnetic resonance imaging；structural magnetic resonance imaging；functional magnetic resonance imaging；diffusion tensor imaging

QU Mingrui   GAO Bingbing   MIAO Yanwei*  

Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

Corresponding author: MIAO Y W, E-mail: ywmiao716@163.com

Conflicts of interest   None.

Received  2023-07-25
Accepted  2023-11-06
DOI: 10.12015/issn.1674-8034.2023.12.022
Cite this article as: QU M R, GAO B B, MIAO Y W. Advances in MRI study of structural and functional changes in the limbic system of Parkinson's disease with depression[J]. Chin J Magn Reson Imaging, 2023, 14(12): 127-131. DOI:10.12015/issn.1674-8034.2023.12.022.

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