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Research progress of magnetic resonance radiomics in predicting the methylation status of MGMT promoter in glioma
LI Ding  WANG Xiaochun 

Cite this article as: LI D, WANG X C. Research progress of magnetic resonance radiomics in predicting the methylation status of MGMT promoter in glioma[J]. Chin J Magn Reson Imaging, 2023, 14(12): 146-150, 171. DOI:10.12015/issn.1674-8034.2023.12.026.


[Abstract] Glioma, accounting for approximately 75% of primary malignant tumors in the central nervous system (CNS), is the most common primary malignant CNS tumor and is associated with a poor prognosis. Temozolomide (TMZ) is a first-line chemotherapy drug used for glioma treatment, and its effectiveness is closely linked to the methylation status of O6-methylguanine-DNA methyltransferase (MGMT). Currently, the detection of MGMT promoter methylation status primarily relies on pyrosequencing, which is time-consuming and susceptible to tumor heterogeneity. In recent years, MRI radiomics and deep learning (DL) have been greatly developed, and the high-throughput data mining approach has partially addressed the issue of tumor heterogeneity. This article provides a review of the latest research progress and limitations of MRI radiomics and DL-based MRI radiomics, with the aim to inspire further research in order to achieve personalized and precise diagnosis and treatment for glioma patients.
[Keywords] glioma；O6-methylguanine-DNA methyltransferase；magnetic resonance imaging；radiomics；deep learning；temozolomide

LI Ding1   WANG Xiaochun2*  

1 College of Medical Imaging, Shanxi Medical University, Taiyuan 030001, China

2 Department of Radiology, First Hospital of Shanxi Medical University, Taiyuan 030001, China

Corresponding author: WANG X C, E-mail: 2010xiaochun@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81971592).
Received  2023-08-27
Accepted  2023-12-02
DOI: 10.12015/issn.1674-8034.2023.12.026
Cite this article as: LI D, WANG X C. Research progress of magnetic resonance radiomics in predicting the methylation status of MGMT promoter in glioma[J]. Chin J Magn Reson Imaging, 2023, 14(12): 146-150, 171. DOI:10.12015/issn.1674-8034.2023.12.026.

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