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• Clinical Article •
The observations on the properties of metabolic network connectivity within striatal-thalamo-cortical circuit in patients with Parkinson's diseases by arterial spin labeling imaging
WANG Yang  SU Hui  WANG Ning  SUN Cunke  LIU Haihua  ZHU Chengwei 

Cite this article as: WANG Y, SU H, WANG N, et al. The observations on the properties of metabolic network connectivity within striatal-thalamo-cortical circuit in patients with Parkinson's diseases by arterial spin labeling imaging[J]. Chin J Magn Reson Imaging, 2024, 15(1): 70-75, 81. DOI:10.12015/issn.1674-8034.2024.01.011.


[Abstract] Objective To investigate the imaging features of striatal-thalamo-cortical (STC) circuit disturbance in patients with Parkinson's disease (PD) from the perspective of metabolic network connectivity.Materials and Methods The data of cerebral blood flow (CBF) from 62 patients with PD and 65 healthy control (HC) subjects were obtained using arterial spin labeling imaging. For both the HC and PD groups, the connectivity properties of metabolic networks within basal ganglia region-cortical circuit were calculated based on their CBF information, including seed-connectivity, cortical-connectivity and modular-connectivity. Permutation test were then employed for the intergroup comparisons of these three types of network connectivity, respectively.Results There were no significant differences in terms of age, sex, education and cognitive scale scores between the two groups (P>0.05). Compared with HC subjects, the value of seed-connectivity in patients with PD was significantly higher in the bilateral inferior temporal gyrus, bilateral fusiform gyrus, bilateral medial frontal gyrus, left middle occipital gyrus and right posterior central gyrus; whereas were significantly lower in the bilateral middle temporal gyrus, left rectus gyrus, left superior temporal gyrus, bilateral inferior frontal gyrus, bilateral precuneus, right supplementary motor area and bilateral inferior parietal gyrus (P<0.05); there were significantly enhanced cortical-connectivity with sensorimotor cortex, whereas significantly weakened cortical-connectivity with motor cortex and parietal-occipital cortex (P<0.05); the modular-connectivity was significantly increased in modules of frontal and motor, modules of sensorimotor and parietal-occipital as well as modules of parietal-occipital and temporal, whereas significantly decreased in modules of frontal and temporal, modules of motor and parietal-occipital and modules of sensorimotor and temporal (P<0.05).Conclusions Patients with PD exhibited with metabolic disturbance of neural network, involving extensive connectivity abnormalities in the STC loop with basal ganglia region as the hub .
[Keywords] Parkinson's disease；magnet resonance imaging；arterial spin labeling imaging；cerebral blood flow；metabolism；network connectivity

WANG Yang1   SU Hui1*   WANG Ning1   SUN Cunke1   LIU Haihua2   ZHU Chengwei1  

1 Department of Radiology, Gaoyou People's Hospital, Yangzhou 225600, China

2 Department of Neuorology, Gaoyou People's Hospital, Yangzhou 225600, China

Corresponding author: SU H, E-mail: sh668800@126.com

Conflicts of interest   None.

Received  2023-08-30
Accepted  2023-12-05
DOI: 10.12015/issn.1674-8034.2024.01.011
Cite this article as: WANG Y, SU H, WANG N, et al. The observations on the properties of metabolic network connectivity within striatal-thalamo-cortical circuit in patients with Parkinson's diseases by arterial spin labeling imaging[J]. Chin J Magn Reson Imaging, 2024, 15(1): 70-75, 81. DOI:10.12015/issn.1674-8034.2024.01.011.

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