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• Clinical Article •
Percent amplitude of fluctuation study in primary angle-closure glaucoma based on resting-state fMRI
TANG Qiuyu  HUANG Binglin  HUANG Xin  XIE Yuyan  WEI Hanlei  HUANG Qin 

Cite this article as: TANG Q Y, HUANG B L, HUANG X, et al. Percent amplitude of fluctuation study in primary angle-closure glaucoma based on resting-state fMRI[J]. Chin J Magn Reson Imaging, 2024, 15(1): 95-100. DOI:10.12015/issn.1674-8034.2024.01.015.


[Abstract] Objective To study the changes of percentage fluctuation amplitude (PerAF) in patients with primary angle-closure glaucoma (PACG) at rest using resting-state functional magnetic resonance imaging (rs-fMRI) technique.Materials and Methods A total of 31 cases of PACG patients diagnosed in the ophthalmology department of Jiangxi Provincial People's Hospital were included. During the same period, 31 sex, age, and duration of education-matched healthy controls (HC) were included in the control group. Whole-brain rs-fMRI scans were performed on each subject to collect PerAF signals. One-sample t-test and two-sample t-test were used to compare PerAF data across and between groups, respectively.Results Compared with HC group, subjects in the PACG patient group had significantly lower PerAF in the left supraparietal gyrus (t=-3.9421, P<0.001), orbital (t=-3.4619, P<0.001), left orbital median frontal gyrus (t=-3.6709, P<0.001), bilateral right median frontal gyrus (t=-3.8257, P<0.001), right inferior frontal gyrus deltoid (t=-3.6708, t=-4.0375, P<0.001); left supramarginal gyrus (t=-3.9570, P<0.001), inferior parietal marginal angular gyrus (t=-3.8230, t=-3.8730, P<0.001), right superior parietal gyrus (t=-4.4581, P<0.001), postcentral gyrus (t=-3.7825, P<0.001), and paracentral lobule (t=-4.0816, P<0.001); right middle temporal gyrus (t=-3.8402, P<0.001); left lingual gyrus (t=-3.5758, P<0.001); left anterior cingulate and paracingulate cingulate gyrus (t=-3.4718, P<0.001), supplementary motor area (t=-3.7209, P<0.001), and right inferior cerebellar area 7b (t=-3.9479, P<0.001) (P<0.001 at voxel level, P<0.05 at cluster level, Gaussian random field corrected).Conclusions Patients with PACG have abnormal PerAF values in multiple brain regions involving primary and higher visual cortex and brain regions associated with visual, emotional, and cognitive regulation.
[Keywords] glaucoma；primary angle-closure glaucoma；resting-state functional magnetic resonance imaging；percent amplitude of fluctuation；magnetic resonance imaging

TANG Qiuyu1   HUANG Binglin2*   HUANG Xin3   XIE Yuyan1   WEI Hanlei1   HUANG Qin1  

1 Graduate School of Jiangxi University of Chinese Medicine, Nanchang 330004, China

2 School of Clinical Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China

3 Department of Ophthalmology, Jiangxi Provincial People's Hospital (the First Affiliated Hospital of Nanchang Medical College), Nanchang 330000, China

Corresponding author: HUANG B L, E-mail: 285217019@qq.com

Conflicts of interest   None.

Received  2023-06-25
Accepted  2023-12-25
DOI: 10.12015/issn.1674-8034.2024.01.015
Cite this article as: TANG Q Y, HUANG B L, HUANG X, et al. Percent amplitude of fluctuation study in primary angle-closure glaucoma based on resting-state fMRI[J]. Chin J Magn Reson Imaging, 2024, 15(1): 95-100. DOI:10.12015/issn.1674-8034.2024.01.015.

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