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• Clinical Article •
Value of cardiac magnetic resonance in the diagnosis of left atrial/left atrial appendage thrombosis in patients with atrial fibrillation: A systematic review and Meta-analysis
YANG Yan  SHI Zhiwei  WANG Yaochang  DU Fengyi  YUAN Xiaojia  XU Yu  LIU Lei  WANG Weitao  CHEN Zhengguang 

Cite this article as: YANG Y, SHI Z W, WANG Y C, et al. Value of cardiac magnetic resonance in the diagnosis of left atrial/left atrial appendage thrombosis in patients with atrial fibrillation: A systematic review and Meta-analysis[J]. Chin J Magn Reson Imaging, 2024, 15(1): 106-112. DOI:10.12015/issn.1674-8034.2024.01.017.


[Abstract] Objective To assess the accuracy of cardiac magnetic resonance (CMR) in evaluating left atrial/ left atrial appendage (LA/LAA) thrombus in patients with atrial fibrillation (AF) and to analyze the difference in diagnostic accuracy of a number of imaging sequences.Materials and Methods Between 2000 and 2022, a systematic search was carried out across multiple databases such as PubMed, Web of Science, Embase, the Cochrane Library, China National Knowledge Infrastructure, VIP databases, Wangfang date bases to compare the effectiveness of CMR with transesophageal echocardiogram (TEE) or surgical pathology in detecting LA/LAA thrombus. The literature was divided into four categories: (1) cine-cardiac magnetic resonance (cine-CMR); (2) contrast enhanced magnetic resonance angiography (CE-MRA); (3) contrast enhanced-cardiac magnetic resonance (CE-CMR); (4) CMR. Statistical analysis was then performed separately to extract relevant clinical data. Extracting pertinent clinical records, the analysis and calculation of sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, receiver operating characteristic, and area under the curve (AUC) were conducted using Stata17.0, Review Manager 5.3, and Meta-DiSc 1.4.Results The evaluation encompassed a total of 868 patients across eleven publications. Cine-CMR exhibits a pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and AUC of 92%, 93%, 12.8, 0.08, 154, 0.93, respectively; CE-MRA demonstrates values of 91%, 100%, 476.4, 0.09, 5 044, 0.99, respectively; CE-CMR demonstrates values of 96%, 100%, 247.5, 0.04, 6 656, 1.00, respectively; and CMR demonstrates values of 99%, 99%, 95.1, 0.01, 7 357, 1.00, respectively.Conclusions CMR has been shown to be a favorable diagnostic method for the detecting and evaluating LA/LAA thrombus, in individuals diagnosed with atrial fibrillation.
[Keywords] cardiac magnetic resonance；atrial fibrillation；left atrial thrombosis；left atrial appendage thrombosis；Meta-analysis；magnetic resonance imaging

YANG Yan   SHI Zhiwei   WANG Yaochang   DU Fengyi   YUAN Xiaojia   XU Yu   LIU Lei   WANG Weitao   CHEN Zhengguang*  

Department of Radiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China

Corresponding author: CHEN Z G, E-mail: guangchen999@sina.com

Conflicts of interest   None.

Received  2022-10-25
Accepted  2023-12-25
DOI: 10.12015/issn.1674-8034.2024.01.017
Cite this article as: YANG Y, SHI Z W, WANG Y C, et al. Value of cardiac magnetic resonance in the diagnosis of left atrial/left atrial appendage thrombosis in patients with atrial fibrillation: A systematic review and Meta-analysis[J]. Chin J Magn Reson Imaging, 2024, 15(1): 106-112. DOI:10.12015/issn.1674-8034.2024.01.017.

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