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• Clinical Article •
Value of ZOOM-mDixon-derived T2*/R2* imaging in preoperative predicting lymph node metastasis in pancreatic ductal adenocarcinoma
LIU Fuyao  ZHANG Jinggang  CHEN Jie  DU Yanan  LI Minglei 

Cite this article as: LIU F Y, ZHANG J G, CHEN J, et al. Value of ZOOM-mDixon-derived T2*/R2* imaging in preoperative predicting lymph node metastasis in pancreatic ductal adenocarcinoma[J]. Chin J Magn Reson Imaging, 2024, 15(1): 119-124. DOI:10.12015/issn.1674-8034.2024.01.019.


[Abstract] Objective To investigate the feasibility of using quantitative T2*/R2* values derived from the ZOOM-mDixon sequence for evaluating lymph node metastasis in pancreatic ductal adenocarcinoma.Materials and Methods A retrospective analysis was conducted on 59 patients with pathologically confirmed pancreatic ductal adenocarcinoma, including 31 patients with lymph node metastasis (LNM) and 28 patients without lymph node metastasis (nLNM). All patients underwent preoperative MRI scans, which included the ZOOM-mDixon sequence. The analysis involved examining clinical data, such as age and preoperative carbohydrate antigen (CA)19-9 levels, routine radiological features including location and morphology, and T2*/R2* values. Intra-class correlation coefficients (ICC) were used to evaluate repeatability, while U-tests, t-tests, or χ2 tests were used to compare differences between the two groups. The receiving operator characteristic (ROC) curve was plotted, and the area under curve (AUC) was calculated to assess the diagnostic performance of quantitative indicators.Results The inter-and intra-group ICC values for T2*/R2* were excellent, ranging from 0.83 to 0.97. No statistically significant differences were observed in age, tumor morphology, short diameter of the tumor, tumor location, preoperative CA19-9, CA125, carcinoma embryonic antigen (CEA) levels between the LNM and nLNM groups. However, gender, long diameter of the lesion, and lesion boundary exhibited statistically significant differences (P values were 0.023, 0.048, 0.040, respectively). There were significant statistical differences in the T2* and R2* values between the two groups (P values <0.05). Compared with the nLNM group, the LNM group exhibited a smaller R2* value [17.63 (15.10, 22.50) /s vs. 24.00 (20.00, 28.30) /s] and a higher T2* value [(63.77±13.95) ms vs. (49.71±12.67) ms]. The AUCs for T2*/R2* values in predicting lymph node metastasis of pancreatic cancer were 0.775 and 0.766, respectively.Conclusions Quantitative T2*/R2* imaging derived from the ZOOM-mDixon sequences can predict preoperative lymph node metastasis of pancreatic ductal adenocarcinoma, offering valuable insights for clinical treatment decisions.
[Keywords] pancreatic ductal adenocarcinoma；water-fat separation technique；magnetic resonance imaging；lymph node metastasis；preoperativ prediction

LIU Fuyao   ZHANG Jinggang*   CHEN Jie   DU Yanan   LI Minglei  

Department of Radiology, Third Affiliated Hospital of Soochow University, Changzhou 213003, China

Corresponding author: ZHANG J G, E-mail: yanqing@126.com

Conflicts of interest   None.

Received  2023-07-20
Accepted  2023-12-26
DOI: 10.12015/issn.1674-8034.2024.01.019
Cite this article as: LIU F Y, ZHANG J G, CHEN J, et al. Value of ZOOM-mDixon-derived T2*/R2* imaging in preoperative predicting lymph node metastasis in pancreatic ductal adenocarcinoma[J]. Chin J Magn Reson Imaging, 2024, 15(1): 119-124. DOI:10.12015/issn.1674-8034.2024.01.019.

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