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• Technical Article •
Comparative study of different doses of gadolinium contrast agent on contrast enhanced T2 FLAIR and T1WI in diagnosis of brain metastases
CAO Minghui  SU Yun  SU Weifeng  MAO Jiaji  LI Yunhua  SHEN Jun 

Cite this article as: CAO M H, SU Y, SU W F, et al. Comparative study of different doses of gadolinium contrast agent on contrast enhanced T2 FLAIR and T1WI in diagnosis of brain metastases[J]. Chin J Magn Reson Imaging, 2024, 15(1): 152-157. DOI:10.12015/issn.1674-8034.2024.01.024.


[Abstract] Objective To determine the efficacy of contrast enhanced T2 fluid attenuated inversion recovery (CE-T2 FLAIR) sequence and contrast enhanced T1 weighted imaging (CE-T1WI) of brain metastases after injection of different doses of gadolinium contrast agent, and to investigate the clinical value of half-dose contrast agent enhanced T2 FLAIR sequence in the diagnosis of brain metastases.Materials and Methods A total of 30 patients with a history of extracranial primary malignant tumors confirmed by pathological diagnosis and brain metastases confirmed by pathological or clinical follow-up were prospectively enrolled. On the basis of conventional non-enhanced T1WI and T2 FLAIR sequences using a 3.0 T MRI equipment, CE-T2 FLAIR and CE-T1WI scans were performed after administration of half-dose (0.05 mmol/kg) gadolinium-based contrast agent (GBCA), followed by fractional supplementation of GBCA to the conventional-dose (0.1 mmol/kg) and double-dose (0.2 mmol/kg). After injection of the GBCA, both CE-T2 FLAIR and CE-T1WI scans were performed. Objective measurements of images were performed by two observers. The contrast-to-noise ratio (CNR), relative-contrast (RC), and percentage increase (PI) of CE-T2 FLAIR and CE-T1WI images under different doses were calculated. Analysis of variance were used to analyze objective measurements between different groups and multiple comparisons were performed when the difference was statistically significant (P<0.05). The t-test was used to analyze the differences between two groups.Results The objective scores were consistent between two observers. There was no significant difference in CNR and RC values among CE-T2 FLAIR images under three different doses of GBCA (P>0.05). Compared with non-enhanced T2 FLAIR scanning, the PI of the lesion was increased. There were significant differences in the CNR and RC values between the CE-T1WI images at three different doses of GBCA (P<0.05). The results of pairwise comparison showed that the CNR and RC values on the doubling-dose CE-T1WI images were significantly higher than those on the half-dose group (P<0.05). The CNR and RC values of CE-T2 FLAIR images at half-dose and conventional-dose were significantly increased compared to CE-T1WI in this group, and the difference was statistically significant (P<0.05). The CNR and RC values of the half-dose CE-T2 FLAIR images were higher than those of the conventional-dose CE-T1WI (P<0.05). Compared with doubling-dose CE-T1WI, the CNR value of the half-dose CE-T2 FLAIR image increased (P<0.05), while the difference in RC value was not statistically significant (P>0.05).Conclusions In comparison with CE-T1WI, the CE-T2 FLAIR sequence with half-dose GBCA could achieve similar image quality and show values in clinical diagnosis of brain metastases.
[Keywords] brain metastases；magnetic resonance imaging；fluid-attenuated inversion recovery sequence；half-dose gadolinium contrast agent；contrast-enhanced

CAO Minghui   SU Yun   SU Weifeng   MAO Jiaji   LI Yunhua   SHEN Jun*  

Department of Radiology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China

Corresponding author: SHEN J, E-mail: shenjun@mail.sysu.edu.cn

Conflicts of interest   None.

Received  2023-11-28
Accepted  2024-01-04
DOI: 10.12015/issn.1674-8034.2024.01.024
Cite this article as: CAO M H, SU Y, SU W F, et al. Comparative study of different doses of gadolinium contrast agent on contrast enhanced T2 FLAIR and T1WI in diagnosis of brain metastases[J]. Chin J Magn Reson Imaging, 2024, 15(1): 152-157. DOI:10.12015/issn.1674-8034.2024.01.024.

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