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Research advance on resting-state functional magnetic resonance imaging in the early diagnosis of Alzheimer's disease
HE Yujie  YAN Shaozhen  LU Jie 

Cite this article as: HE Y J, YAN S Z, LU J. Research advance on resting-state functional magnetic resonance imaging in the early diagnosis of Alzheimer's disease[J]. Chin J Magn Reson Imaging, 2024, 15(1): 173-178. DOI:10.12015/issn.1674-8034.2024.01.029.


[Abstract] Alzheimer's disease (AD) is a degenerative disease of the central nervous system characterized by cognitive impairment. There is a preclinical period of approximately 20 years before the onset of clinical symptoms, making it the optional time window for disease intervention. Therefore, the early diagnosis of AD is essential for disease delay and prognosis improvement. Resting-state functional magnetic resonance imaging (rs-fMRI) has the advantages of non-invasive and high spatial-temporal resolution. It is one of the most widely used neuroimaging techniques to study brain functional activity abnormalities in AD, which provides the possibility to find non-invasive markers of early AD. Based on rs-fMRI techniques, we reviewed the application value in the early diagnosis of AD in this article, in order to find non-invasive imaging markers for early monitoring of AD.
[Keywords] Alzheimer's disease；mild cognitive impairment；subjective cognitive decline；resting-state functional magnetic resonance imaging；magnetic resonance imaging；early diagnosis

HE Yujie   YAN Shaozhen   LU Jie*  

Department of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical University, Beijing Key Laboratory of MRI and Brain Informatics, Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing 100053, China

Corresponding author: LU J, E-mail: imaginglu@hotmail.com

Conflicts of interest   None.

Received  2023-09-07
Accepted  2023-12-07
DOI: 10.12015/issn.1674-8034.2024.01.029
Cite this article as: HE Y J, YAN S Z, LU J. Research advance on resting-state functional magnetic resonance imaging in the early diagnosis of Alzheimer's disease[J]. Chin J Magn Reson Imaging, 2024, 15(1): 173-178. DOI:10.12015/issn.1674-8034.2024.01.029.

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