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Theoretical basis and MRI research progress of probiotics in the treatment of mental diseases
ZHANG Miao  ZHOU Jing  WU Xiaoling  LI Zhonglin  ZOU Zhi  LI Yongli 

Cite this article as: ZHANG M, ZHOU J, WU X L, et al. Theoretical basis and MRI research progress of probiotics in the treatment of mental diseases[J]. Chin J Magn Reson Imaging, 2024, 15(1): 179-183. DOI:10.12015/issn.1674-8034.2024.01.030.


[Abstract] Gut microbiota (GM) acts on the brain through the brain-gut axis and plays an important role in the occurrence and development of mental diseases. Probiotics can have beneficial effects on the brain by maintaining GM homeostasis and intestinal barrier integrity, thus ameliorating the negative physiological effects caused by mental illness. MRI can be used to observe changes in the function and structure of the host brain when probiotics treat psychiatric disorders.This paper summarizes the recent research on the evaluation of probiotics in the treatment of mental disorders (depression, schizophrenia, autism spectrum disorder, obsessive compulsive disorder, anxiety disorder) by acting on brain-gut-microbiome axis based on MRI. It provides a new idea and objective brain imaging basis for the treatment of mental diseases.
[Keywords] mental disease；magnetic resonance imaging；probiotics；the brain-gut-microbiome axis

ZHANG Miao1   ZHOU Jing2   WU Xiaoling3   LI Zhonglin1   ZOU Zhi1   LI Yongli2*  

1 Department of Medical Imaging, People's Hospital of Zhengzhou University/Henan Provincial People's Hospital, Zhengzhou 450003, China

2 Department of Health Management, People's Hospital of Zhengzhou University/Henan Provincial People's Hospital, Zhengzhou 450003, China

3 Department of Nuclear Medicine, Henan Proincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou 450003, China

Corresponding author: LI Y L, E-mail: shyliyongli@126.com

Conflicts of interest   None.

Received  2023-08-31
Accepted  2023-12-08
DOI: 10.12015/issn.1674-8034.2024.01.030
Cite this article as: ZHANG M, ZHOU J, WU X L, et al. Theoretical basis and MRI research progress of probiotics in the treatment of mental diseases[J]. Chin J Magn Reson Imaging, 2024, 15(1): 179-183. DOI:10.12015/issn.1674-8034.2024.01.030.

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