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Progress of multimodal MRI in end-stage renal disease complicated with cognitive impairment
LU Ting  LU Ji 

Cite this article as: LU T, LU J. Progress of multimodal MRI in end-stage renal disease complicated with cognitive impairment[J]. Chin J Magn Reson Imaging, 2024, 15(1): 229-234. DOI:10.12015/issn.1674-8034.2024.01.039.


[Abstract] Cognitive impairment is highly prevalent in patients with end-stage renal disease, and this impairment, which involves a range of cognitive domains including attention, memory, and executive functioning, severely diminishes patients' quality of life. However, the exact mechanisms underlying this neurocognitive deficit are unknown, making it challenging to detect and manage this cognitive impairment at an early stage. Multimodal magnetic resonance imaging has yielded many results in this area in recent years and holds the promise of selecting imaging biomarkers to guide early screening and diagnosis of cognitive deficits in patients with chronic kidney disease (CKD). This paper will briefly describe the research progress of various emerging MRI technologies and artificial intelligence in end-stage renal disease (ESRD) patients with cognitive impairment, and try to reveal the connection between brain structure, function, perfusion, metabolism, neurovascular coupling and cognitive dysfunction in ESRD patients, so as to help clinical understanding of the potential neuronal mechanism of brain defects in ESRD patients. It is beneficial to the early diagnosis, treatment and follow-up of ESRD patients with cognitive impairment.
[Keywords] end-stage renal disease；cognitive impairment；magnetic resonance imaging；multimodal；functional brain imaging；hemodialysis；brain impairment

LU Ting1, 2   LU Ji1, 2*  

1 The First College of Clinical Medical Science, China Three Gorges University, Yichang 443000, China

2 Department of Radiology, Yichang Central People's Hospital, Yichang 443000, China

Corresponding author: LU J, E-mail: 15926951408@163.com

Conflicts of interest   None.

Received  2023-11-14
Accepted  2024-01-09
DOI: 10.12015/issn.1674-8034.2024.01.039
Cite this article as: LU T, LU J. Progress of multimodal MRI in end-stage renal disease complicated with cognitive impairment[J]. Chin J Magn Reson Imaging, 2024, 15(1): 229-234. DOI:10.12015/issn.1674-8034.2024.01.039.

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