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• Clinical Article •
Resting MRI study on the effect of δ-catenin over expression on short-term brain cognitive function in breast cancer patients after chemotherapy
XUE Mingtuan  DU Wei  CAO Jiajun  SONG Duan  ZHANG Junyi  MIAO Yanwei 

Cite this article as: XUE M T, DU W, CAO J J, et al. Resting MRI study on the effect of δ-catenin over expression on short-term brain cognitive function in breast cancer patients after chemotherapy[J]. Chin J Magn Reson Imaging, 2024, 15(2): 56-62. DOI:10.12015/issn.1674-8034.2024.02.008.


[Abstract] Objective In this study, resting state fMRI was used to investigate the changes of brain cognitive function after 2 cycles of anthracycline cyclophosphamide (AC) chemotherapy in breast cancer patients with different expression of δ-catenin.Materials and Methods A total of 66 patients with breast cancer confirmed by pathology and received standardized chemotherapy for the first time were prospectively collected. According to the level of tissue serum δ-catenin, they were divided into δ-catenin high expression group (n=31), δ-catenin low expression group (n=35) and healthy control (HC) group (n=36). All subjects received neuropsychological score and brain resting state fMRI and 3D-T1 weighted imaging before and after 2 cycles of chemotherapy. The functional indexes of brain resting state, including amplitude of low frequency fluctuation (ALFF), fractional amplitude of low frequency fluctuation (fALFF) and regional homogeneity (ReHo), the neuropsychological scores and the MRI index of brain resting state function were compared and analyzed before and after chemotherapy.Results The expression of human epidermal growth factor receptor 2 (HER-2) in δ-catenin high expression group was significantly higher than that in low expression group (P<0.05). The neurological scores of breast cancer patients before and after chemotherapy showed that there were significant differences in Functional Assessment of Cancer Therapy-Cognitive (FACT-Cog)-SUM, Perceived Cognitive Abilities (PCA), Mini Mental State Examination (MMSE), Montreal Cognitive Assessment (MOCA), Digital Symbol Substitution Test (DSST) and Auditory Verbal Learning Test (AVLT), Line-B scores in δ-catenin high expression group, while only AVLT-long-term memory scores in low expression group had significant differences (P<0.05). Compared with those before chemotherapy, there were significant differences in ALFF and ReHo values in some brain regions (P<0.05). The ALFF values of right anterior cingulate and paracingulate gyrus in δ-catenin low expression group decreased after chemotherapy, while those in δ-catenin high expression group decreased after chemotherapy in right cerebellar hemisphere area 4-5, bilateral insular and left lingual gyrus. Among the ReHo indexes, the ReHo values of the left inferior orbital frontal gyrus decreased in the δ-catenin low expression group after chemotherapy, while those in the left superior marginal gyrus and left triangular inferior frontal gyrus decreased in the δ-catenin high expression group (P<0.05).Conclusions The high expression of δ-catenin protein further aggravates the damage of brain cognitive function induced by chemotherapy in patients with breast cancer, which is mainly related to the executive regulation of cognitive function and other related brain regions.
[Keywords] breast cancer；δ-catenin；chemotherapy-related cognitive impairment；longitudinal study；resting-state brain function；magnetic resonance imaging

XUE Mingtuan1, 2   DU Wei1   CAO Jiajun1   SONG Duan2   ZHANG Junyi3   MIAO Yanwei1*  

1 Department of Radiology, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

2 CT and MR Departments, Affiliated Hospital of Chifeng University, Chifeng 024000, China

3 Department of Pathology, Affiliated Hospital of Chifeng University, Chifeng 024000, China

Corresponding author: MIAO Y W, E-mail: ywmiao716@163.com

Conflicts of interest   None.

Received  2023-11-22
Accepted  2024-01-21
DOI: 10.12015/issn.1674-8034.2024.02.008
Cite this article as: XUE M T, DU W, CAO J J, et al. Resting MRI study on the effect of δ-catenin over expression on short-term brain cognitive function in breast cancer patients after chemotherapy[J]. Chin J Magn Reson Imaging, 2024, 15(2): 56-62. DOI:10.12015/issn.1674-8034.2024.02.008.

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