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• Technical Article •
Application value of VMHC and ReHo in evaluating tDCS in improving cognitive impairment after stroke
ZHONG Jiali  JING Xiaoshan  LIANG Ying 

Cite this article as: ZHONG J L, JING X S, LIANG Y. Application value of VMHC and ReHo in evaluating tDCS in improving cognitive impairment after stroke[J]. Chin J Magn Reson Imaging, 2024, 15(2): 129-134. DOI:10.12015/issn.1674-8034.2024.02.019.


[Abstract] Objective Exploring the application value of voxel-mirror homotopic connectivity (VMHC) and regional homogeneity (ReHo) in evaluating transcranial direct current stimulation (tDCS) in improving cognitive impairment after stroke.Materials and Methods A total of 47 patients with post-stroke cognitive impairment (PSCI) were prospectively included and randomly assigned to the tDCS group and sham stimulation group. Among them, 23 patients were in the tDCS group and 24 patients were in the sham stimulation group. Use Mann Whitney U-test to compare the differences in cognitive scale scores between two groups of patients at baseline and 15 days after tDCS or sham stimulation treatment. Use paired t-test to compare the differences in VMHC and ReHo result between two groups of patients at baseline and 15 days after tDCS or sham stimulation treatment. Collect and extract VMHC and ReHo values of different brain regions for correlation analysis with changes in scale scores before and after treatment.Results The Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores of the tDCS group and the sham stimulation group after treatment were better than before treatment, but the tDCS group had better treatment effect. After treatment, the MMSE and MoCA scores improved significantly compared to before treatment, with a statistically significant difference (P<0.05); VMHC results: After treatment, the VMHC values in the bilateral insula and anterior cuneiform lobes of patients in the tDCS group increased (P<0.05, FDR correction), while the VMHC values in the bilateral superior occipital gyrus of patients in the sham stimulation group increased (P<0.05, FDR correction); ReHo results: After treatment, the ReHo values in the anterior cingulate gyrus and inferior parietal angular gyrus of patients in the tDCS group increased (P<0.05, FDR correction), while there was no significant difference in brain regions between the sham stimulation group and before treatment; Correlation analysis: After treatment, the increase in VMHC in the bilateral anterior cuneiform lobes of patients in the tDCS group showed a positive correlation with changes in MMSE and MoCA scales; MMSE (r=0.47, P=0.02); MoCA (r=0.43, P=0.04), while there was no significant correlation between other brain regions and changes in MMSE and MoCA scales.Conclusions The cognitive rehabilitation effect of tDCS combined with conventional rehabilitation treatment on PSCI patients is better than that of conventional rehabilitation treatment alone. The application of VMHC and ReHo found that the treatment mechanism of tDCS may be related to improving the functional connectivity and spontaneous activity of some brain regions between the bilateral hemispheres in the default mode network (DMN) and salience network (SN).
[Keywords] stroke；cerebral infarction；post stroke cognitive impairment；resting state；voxel-mirror homotopic connectivity；regional homogeneity；magnetic resonance imaging

ZHONG Jiali1   JING Xiaoshan2   LIANG Ying1*  

1 Department of Biomedical Engineering, Capital Medical University, Beijing 100069, China

2 Department of Rehabilitation, Beijing LuHe Hospital, Capital Medical University, Beijing 101149, China

Corresponding author: LIANG Y, E-mail: yingliang@ccmu.edu.cn

Conflicts of interest   None.

Received  2023-09-01
Accepted  2024-01-15
DOI: 10.12015/issn.1674-8034.2024.02.019
Cite this article as: ZHONG J L, JING X S, LIANG Y. Application value of VMHC and ReHo in evaluating tDCS in improving cognitive impairment after stroke[J]. Chin J Magn Reson Imaging, 2024, 15(2): 129-134. DOI:10.12015/issn.1674-8034.2024.02.019.

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