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• Review •
Research progress on freezing of gait in Parkinson's disease based on multimodal MRI
HOU Junbao  SHI Qiye  WANG Yang  PENG Xiaohan  CAO Danna 

Cite this article as: HOU J B, SHI Q Y, WANG Y, et al. Research progress on freezing of gait in Parkinson's disease based on multimodal MRI[J]. Chin J Magn Reson Imaging, 2024, 15(2): 178-182. DOI:10.12015/issn.1674-8034.2024.02.028.


[Abstract] Freezing of gait (FOG) is a paroxysmal gait disturbance observed in patients with advanced-stage Parkinson's disease, significantly impacting their quality of life. However, there is still no clear elucidation of the pathogenesis and changes in brain structure and function during the course of the disease. In recent years, multimodal MRI imaging techniques, primarily utilizing diffusion tensor imaging (DTI), three-dimensional T1-weighted imaging (3D T1WI) and functional MRI (fMRI) have been widely employed in the exploration of the pathogenesis of neurological disorders. These techniques have provided new insights into the underlying mechanisms of FOG. Recent research indicates a close association between changes in visual, motor, and cognitive networks and the occurrence of FOG. The author aims to conduct a review by analyzing recent domestic and international literature, summarize multimodal MRI exploration of structural and functional changes in the brains of Parkinson's disease patients with freezing of gait. The review discusses the current controversial aspects of FOG research and proposes new perspectives for future comprehensive elucidation of its pathogenesis using multimodal MRI.
[Keywords] Parkinson's disease；freezing of gait；diffusion tensor imaging；magnetic resonance imaging；functional connectivity；brain network

HOU Junbao1   SHI Qiye1   WANG Yang2   PENG Xiaohan1   CAO Danna2*  

1 Graduate School of Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China

2 Department of CT & MR, the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China

Corresponding author: CAO D N, E-mail: hljanna@126.com

Conflicts of interest   None.

Received  2023-10-16
Accepted  2024-01-31
DOI: 10.12015/issn.1674-8034.2024.02.028
Cite this article as: HOU J B, SHI Q Y, WANG Y, et al. Research progress on freezing of gait in Parkinson's disease based on multimodal MRI[J]. Chin J Magn Reson Imaging, 2024, 15(2): 178-182. DOI:10.12015/issn.1674-8034.2024.02.028.

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