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• Clinical Article •
Alterations of brain mirror homotopic functional connectivity in postpartum women: A resting-state fMRI study
ZHANG Kaihua  LIN Jiayu  SU Wei  GAO Yingli  LI Na  DU Yuxuan  LIN Xingru  WANG Jing  ZHAO Shijia  DU Xiaoxia 

Cite this article as: ZHANG K H, LIN J Y, SU W, et al. Alterations of brain mirror homotopic functional connectivity in postpartum women: A resting-state fMRI study[J]. Chin J Magn Reson Imaging, 2024, 15(3): 7-12. DOI:10.12015/issn.1674-8034.2024.03.002.


[Abstract] Objective Voxel-mirrored homotopic connectivity (VMHC) was used to study the difference of functional connection between parity points in the brain of postpartum women and nulliparous women to explore the changes of brain function of postpartum women.Materials and Methods The resting-state functional magnetic resonance imaging (rs-fMRI) data and structural image data of 39 postpartum women and 26 nulliparous women were collected for VMHC analysis, and the differences of VMHC between groups were analyzed by a two-sample t-test. Moreover, the demographic data and Interpersonal Reactivity Index-C (IRI-C) scores of the two groups were collected.Results The analysis of the IRI-C scale found a significant difference in empathy between postpartum women and nulliparous women (P<0.001). Compared with the nulliparous women, the postpartum women showed significantly decreased VMHC in bilateral fusiform gyrus, parahippocampal gyrus, middle frontal gyrus, medial frontal gyrus, anterior central gyrus, putamen and lentiform nucleus and other brain regions (FDR corrected, voxel level P<0.001, cluster level P<0.05, two tailed), while they showed significantly increased VMHC in bilateral precuneus, parietal lobules and subparietal lobules (FDR corrected, voxel level P<0.01, cluster level P<0.05, two tailed).Conclusions After giving birth for the first time, the functional connections between hemispheres in some brain regions of women have changed, which may be the adaptive changes of women's parenting behavior during the postpartum period.
[Keywords] postpartum women；nulliparous women；maternal and infant attachment；resting-state functional magnetic resonance imaging；voxel-mirrored homotopic connectivity

ZHANG Kaihua1   LIN Jiayu1   SU Wei1   GAO Yingli1   LI Na1   DU Yuxuan1   LIN Xingru1   WANG Jing2   ZHAO Shijia1   DU Xiaoxia3*  

1 College of Psychology, Shandong Normal University, Jinan 250014, China

2 Department of International Students Training, Shandong Normal University, Jinan 250014, China

3 Department of Psychology, Shanghai University of Sport, Shanghai 200438, China

Corresponding author: DU X X, E-mail: duxiaoxia@sus.edu.cn.

Conflicts of interest   None.

Received  2023-09-26
Accepted  2024-02-26
DOI: 10.12015/issn.1674-8034.2024.03.002
Cite this article as: ZHANG K H, LIN J Y, SU W, et al. Alterations of brain mirror homotopic functional connectivity in postpartum women: A resting-state fMRI study[J]. Chin J Magn Reson Imaging, 2024, 15(3): 7-12. DOI:10.12015/issn.1674-8034.2024.03.002.

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