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• Clinical Article •
Differential diagnosis of angiomatous meningioma and atypical meningioma based on contrast enhanced T1-weighted images histogram analysis
HAN Tao  LIU Xianwang  JIANG Jian  ZHOU Fengyu  DONG Wenjie  ZHANG Bin  ZHOU Junlin 

Cite this article as: HAN T, LIU X W, JIANG J, et al. Differential diagnosis of angiomatous meningioma and atypical meningioma based on contrast enhanced T1-weighted images histogram analysis[J]. Chin J Magn Reson Imaging, 2024, 15(3): 37-42. DOI:10.12015/issn.1674-8034.2024.03.007.


[Abstract] Objective To investigate the value of structural MRI features and enhanced T1-weighted images histogram analysis in the differential diagnosis of atypical meningioma (AtM) and angiomatous meningioma (AnM).Materials and Methods The clinical, imaging and pathological data of AtM (n=40) and AnM (n=30) were collected retrospectively. The tumor was delineated layer-by-layer on axial enhanced T1-weighted images by MaZda software and histogram parameters of tumor enhancement areas were obtained. Structural MRI characteristics were compared using the chi-square test or Fisher's exact test. Histogram parameters were compared between the two groups using independent samples t-tests or Mann-Whitney U-tests, and diagnostic efficacy between the two groups was assessed by receiver operating characteristic (ROC) curves.Results The incidence of tumor necrosis was significantly higher in the AtM group (75.0%) than in the AnM group (36.7%) (P=0.001). The mean (P=0.003), 1st percentile (P<0.001), 10th percentile (P=0.001), and 50th percentile (P=0.009) of the AnM were greater than those of the AtM. ROC curve analysis showed that tumor necrosis + combined histogram parameters had the optimal differential diagnostic efficacy between the two, with area under the curve, sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of 0.858 (0.753-0.930), 95.00%, 66.67%, 82.86%, 79.20%, and 90.90%.Conclusions The conventional MRI features and histogram analysis based on enhanced T1-weighted images is helpful in the preoperative non-invasive differentiation of AnM and AtM, of which the diagnostic efficacy is highest in the tumor necrosis + combined histogram parameters.
[Keywords] meningioma；angiomatous meningioma；atypical meningioma；magnetic resonance imaging；histogram analysis

HAN Tao1, 2, 3, 4   LIU Xianwang1, 2, 3, 4   JIANG Jian1, 2, 3, 4   ZHOU Fengyu1, 2, 3, 4   DONG Wenjie1, 2, 3, 4   ZHANG Bin1, 2, 3, 4   ZHOU Junlin1, 3, 4*  

1 Department of Radiology, Lanzhou University Second Hospital, Lanzhou 730030, China

2 Second Clinical School, Lanzhou University, Lanzhou 730030, China

3 Key Laboratory of Medical Imaging of Gansu Province, Lanzhou 730030, China

4 Gansu International Scientific and Technological Cooperation Base of Medical Imaging Artificial Intelligence, Lanzhou 730030, China

Corresponding author: ZHOU J L, E-mail: lzuzjl601@163.com

Conflicts of interest   None.

Received  2023-09-12
Accepted  2024-01-31
DOI: 10.12015/issn.1674-8034.2024.03.007
Cite this article as: HAN T, LIU X W, JIANG J, et al. Differential diagnosis of angiomatous meningioma and atypical meningioma based on contrast enhanced T1-weighted images histogram analysis[J]. Chin J Magn Reson Imaging, 2024, 15(3): 37-42. DOI:10.12015/issn.1674-8034.2024.03.007.

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