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• Clinical Article •
Value of 4D-Flow MRI in evaluating left ventricular outflow tract peak velocity in hypertrophic cardiomyopathy: A proof-of-concept study
XU Jing  CHEN Xiuyu  YIN Gang  YAN Weipeng  LU Minjie  ZHAO Shihua 

Cite this article as: XU J, CHEN X Y, YIN G, et al. Value of 4D-Flow MRI in evaluating left ventricular outflow tract peak velocity in hypertrophic cardiomyopathy: A proof-of-concept study[J]. Chin J Magn Reson Imaging, 2024, 15(3): 56-61. DOI:10.12015/issn.1674-8034.2024.03.010.


[Abstract] Objective To explore the feasibility of using four-dimensional flow (4D-Flow) magnetic resonance imaging (MRI) in left ventricle, and to evaluate the reproducibility and consistency of quantification of left ventricular outflow tract (LVOT) peak velocity by comparing with two-dimensional flow (2D-Flow) MRI and echocardiography.Materials and Methods This research was a prospective and cross-sectional study. Twenty-one patients with hypertrophic cardiomyopathy (HCM) underwent cardiac MRI 2D-Flow and 4D-Flow data acquisition on a 3.0 T MRI scanner August 2022 to January 2023. Echocardiography within one weeks before or after MRI examination were collected. The inter-class correlation coefficient (ICC), coefficient of variation (COV) and Bland-Altman analysis were used to evaluate the reproducibility and consistency of LVOT peak velocity derived from 2D-Flow and 4D-Flow, and the relationship between 2D/4D-Flow and echocardiography was analyzed by Pearson correlation analysis.Results The ICC of 2D-Flow and 4D-Flow were 0.999/0.999 and 0.995/0.992, respectively, and the COV of 2D-Flow and 4D-Flow were 0.5%/0.5% and 2.4%/2.6%, respectively. 4D-Flow was moderately correlated with echocardiography (r=0.574, P=0.006), but the consistency between the two was poor (ICC=0.375, P=0.013). Besides, there were no significant consistency and correlation between 2D-Flow and 4D-Flow/echocardiography.Conclusions 4D-Flow cardiac MRI can visualize the flow patterns within the heart. The peak velocity of LVOT derived from 4D-Flow is highly reproducible and is significantly correlated with echocardiography.
[Keywords] hypertrophic cardiomyopathy；four-dimensional flow；two-dimensional flow；cardiac magnetic resonance；magnetic resonance imaging

XU Jing   CHEN Xiuyu   YIN Gang   YAN Weipeng   LU Minjie   ZHAO Shihua*  

Department of Magnetic Resonance Imaging, Fuwai Hospital, National Center for Cardiovascular Diseases of China, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing 100037, China

Corresponding author: ZHAO S H, E-mail: cjrzhaoshihua2009@163.com

Conflicts of interest   None.

Received  2023-08-11
Accepted  2024-02-23
DOI: 10.12015/issn.1674-8034.2024.03.010
Cite this article as: XU J, CHEN X Y, YIN G, et al. Value of 4D-Flow MRI in evaluating left ventricular outflow tract peak velocity in hypertrophic cardiomyopathy: A proof-of-concept study[J]. Chin J Magn Reson Imaging, 2024, 15(3): 56-61. DOI:10.12015/issn.1674-8034.2024.03.010.

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