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• Clinical Article •
Diagnostic value of native T1 and ECV in myocardial amyloidosis: A Meta-analysis
WANG Guohui  MENG Li  BAO Haihua  LI Wenxin 

Cite this article as: WANG G H, MENG L, BAO H H, et al. Diagnostic value of native T1 and ECV in myocardial amyloidosis: A Meta-analysis[J]. Chin J Magn Reson Imaging, 2024, 15(3): 81-85, 92. DOI:10.12015/issn.1674-8034.2024.03.014.


[Abstract] Objective The Meta-analysis was used to explore the diagnostic value of native T1 and extracellular volume fraction (ECV) for cardiac amyloidosis (CA).Materials and Methods PubMed, Embase, Cochrane Library, Web of Science, Wanfang Database, CBM, VIP and CNKI were searched to explore the value of T1 and ECV of the diagnostic value in CA. The search time was from the establishment of the database to November 2022. Two researchers independently completed the literature screening, extracted the relevant data included in the literature and evaluated the quality. The bias risk was evaluated and statistically analyzed by Revman 5.3, Stata 16.0 and Meta-Disc 1.4. Heterogeneity and publication bias analysis were carried out. Sensitivity analysis was used to verify the stability and reliability of Meta-analysis results.Results A total of 12 articles (1 045 patients) were included. Meta-analysis showed that sensitivity (Sen), specificity (Spe), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), area under the curve (AUC) and 95% confidence interval (CI) of T1 diagnostic CA were 86% (95% CI: 82%-89%), 86% (95% CI: 80%-91%), 6.2 (95% CI: 4.2-9.3), 0.16 (95% CI: 0.12-0.22), 38 (95% CI: 19-75), 0.92 (95% CI: 0.90-0.94). The Sen, Spe, PLR, NLR, DOR, and AUC of ECV diagnostic CA were 90% (95% CI: 83%-94%), 90% (95% CI: 83%-94%), 8.8 (95% CI: 5.3-14.6), 0.11 (95% CI: 0.07-0.19), 79 (95% CI: 38-162), and 0.95 (95% CI: 0.93-0.97).Conclusions Native T1 value and ECV have high diagnostic value for CA and can provide imaging basis for the early diagnosis of CA.
[Keywords] cardiac amyloidosis；cardiac magnetic resonance；T1 mapping；extracellular volume fraction；Meta-analysis

WANG Guohui1   MENG Li1*   BAO Haihua1   LI Wenxin2  

1 Medical Imaging Center, Qinghai University Affiliated Hospital, Xining 810001, China

2 Department of Ultrasound Medicine, Qinghai University Affiliated Hospital, Xining 810001, China

Corresponding author: MENG L, E-mail: qh_mengli@126.com

Conflicts of interest   None.

Received  2023-05-30
Accepted  2024-02-23
DOI: 10.12015/issn.1674-8034.2024.03.014
Cite this article as: WANG G H, MENG L, BAO H H, et al. Diagnostic value of native T1 and ECV in myocardial amyloidosis: A Meta-analysis[J]. Chin J Magn Reson Imaging, 2024, 15(3): 81-85, 92. DOI:10.12015/issn.1674-8034.2024.03.014.

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