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• Clinical Article •
The relationship between the abnormality of multilayer networks and emotional impairments in sudden sensorineural hearing loss patients with migraine
MIAO Xiuqian  XU Jinjing  LI Biao  FENG Yuan  CHEN Yuchen  YIN Xindao 

Cite this article as: MIAO X Q, XU J J, LI B, et al. The relationship between the abnormality of multilayer networks and emotional impairments in sudden sensorineural hearing loss patients with migraine[J]. Chin J Magn Reson Imaging, 2024, 15(4): 15-19. DOI:10.12015/issn.1674-8034.2024.04.003.


[Abstract] Objective To explore the relationship between sudden sensorineural hearing loss (SSNHL) with migraine and emotional impairments using multilayer neural network technology.Materials and Methods We recruited 41 SSNHL with migraine patients and 47 healthy controls in this study. And all participants underwent evaluation of hearing abilities, migraine, neuropsychological assessments, as well resting-state functional brain imaging. Multilayer network analysis was computed to identify dynamic changes in brain global networks. Graph theoretical network analysis (GRETNA) was used to process blood oxygen level dependent (BOLD) data, and Pearson correlation analysis was conducted to calculate the correlation between functional MRI data and emotional impairments.Results The two groups were well matched in age, sex and education level. The mean hearing thresholds of both ears in SSNHL patients with migraine were significantly higher than healthy controls. Moreover, the scores of anxiety and depression were significantly higher in otologic migraine patients. There was no significant difference in overall modularity between the patients and healthy controls. But significant differences of network switching rates in the right Rolandic operculum and middle cingulate cortex (MCC), left cuneus and inferior occipital gyrus (P<0.005, false discovery rate correction) were observed. Additionally, the conversion rate of MCC was negatively correlated with depression in SSNHL patients with migraine group (r=-0.41, P=0.008).Conclusions The decrease of switching rate in SSNHL patients with migraine is closely related to depression, which helps to elucidate the neuropathological basis of emotional impairments induced by SSNHL with migraine.
[Keywords] sudden sensorineural hearing loss with migraine；neural imaging；magnetic resonance imaging；multilayer network；anxiety；depression

MIAO Xiuqian1   XU Jinjing2*   LI Biao2   FENG Yuan1   CHEN Yuchen1   YIN Xindao1  

1 Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

2 Department of Otolaryngology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

Corresponding author: XU J J, E-mail: xjj0117ent@163.com

Conflicts of interest   None.

Received  2023-09-15
Accepted  2024-03-25
DOI: 10.12015/issn.1674-8034.2024.04.003
Cite this article as: MIAO X Q, XU J J, LI B, et al. The relationship between the abnormality of multilayer networks and emotional impairments in sudden sensorineural hearing loss patients with migraine[J]. Chin J Magn Reson Imaging, 2024, 15(4): 15-19. DOI:10.12015/issn.1674-8034.2024.04.003.

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