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• Clinical Article •
Brain structure and functional magnetic resonance imaging in patients with breast cancer undergoing chemotherapy
SONG Yaqi  LI Yifan  XIA Jianguo  TIAN Weizhong 

Cite this article as: SONG Y Q, LI Y F, XIA J G, et al. Brain structure and functional magnetic resonance imaging in patients with breast cancer undergoing chemotherapy[J]. Chin J Magn Reson Imaging, 2024, 15(4): 20-24, 31. DOI:10.12015/issn.1674-8034.2024.04.004.


[Abstract] Objective To investigate the changes of gray matter volume (GMV) and functional connectivity (FC) of some brain regions in patients with breast cancer undergoing chemotherapy.Materials and Methods The study included 29 patients with breast cancer before chemotherapy treatment (C-) and 30 patients with breast cancer after chemotherapy treatment (C+). We performed psychological cognitive testing, structural and resting functional MRI (fMRI) scans respectively. Voxel-based morphometry (VBM) was used to analyze GMV, and the regions with volumetric variation were selected as regions of interest interest (ROI) for whole-brain FC analysis.Results Compared with the C- group, patients with C+ had reduced GMV in the left middle occipital gyrus (MNI: X, Y, Z=-10.5, -105.0, 0.0) and the right calcarine fissure and surrounding cortex (MNI: X, Y, Z=15.0, -103.5, -1.5). With the left middle occipital gyrus as the seed point, the FC with the temporal pole: superior temporal gyrus (MNI: X, Y, Z=63, 3, -3) and the left superior temporal gyrus (MNI: X, Y, Z=-54, -12, 3) was weakened. With the right calcarine fissure and surrounding cortex as the seed point, the FC with the left lingual gyrus (MNI: X, Y, Z=-33, -87, -15) was weakened. There was no significant correlation between GMV and FC values and psychological cognitive outcomes in C+ patients.Conclusions After chemotherapy, the volume of gray matter in some brain regions of breast cancer patients is changed, and FCs with multiple brain regions are impaired, which may be one of the neuropathological bases of cognitive, emotional and behavioral disorders.
[Keywords] breast cancer；chemotherapy-related cognitive impairment；functional magnetic resonance imaging；magnetic resonance imaging；gray matter volume；voxel-based morphometry；functional connectivity

SONG Yaqi1, 2   LI Yifan3   XIA Jianguo2   TIAN Weizhong2*  

1 Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou 225309, China

2 Department of Medical Imaging, the Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou 225399, China

3 Nantong University Medical College, Nantong 226001, China

Corresponding author: TIAN W Z, E-mail: jstztwz@163.com

Conflicts of interest   None.

Received  2023-09-22
Accepted  2024-04-08
DOI: 10.12015/issn.1674-8034.2024.04.004
Cite this article as: SONG Y Q, LI Y F, XIA J G, et al. Brain structure and functional magnetic resonance imaging in patients with breast cancer undergoing chemotherapy[J]. Chin J Magn Reson Imaging, 2024, 15(4): 20-24, 31. DOI:10.12015/issn.1674-8034.2024.04.004.

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