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• Clinical Article •
Feasibility study of the MAGiC technique for quantitative assessment of primary osteoporosis
WANG Wenjuan  ZOU Yuefen  HU Lei  LIU Xiaofeng  CHAI Liuyong 

Cite this article as: WANG W J, ZOU Y F, HU L, et al. Feasibility study of the MAGiC technique for quantitative assessment of primary osteoporosis[J]. Chin J Magn Reson Imaging, 2024, 15(4): 99-105. DOI:10.12015/issn.1674-8034.2024.04.016.


[Abstract] Objective To evaluate the application value of magnetic resonance image compilation (MAGiC) sequence in primary osteoporosis.Materials and Methods Prospectively recruited health screening volunteers who completed a low-dose chest CT scans between May 2023 and September 2023. All volunteers voluntarily underwent routine lumbar MRI and MAGiC sequence scans. The average bone mineral density (BMD) value of the lumbar spine based on low-dose chest CT, the VBQ value based on conventional T1-weighted imaging, and the VBQ-magic, average T1 relaxation time (T1av), average T2 relaxation time (T2av), average proton density (PDav) values based on MAGiC T1-weighted imaging were measured, and the body mass index (BMI) value was calculated. Patients were categorized into a normal bone group (63 cases), a bone loss group (43 cases), and an osteoporosis group (22 cases) based on the osteoporosis diagnostic criteria of lumbar quantitative computed tomography (QCT). Multiple group comparisons were performed using one-way ANOVA or Kruskal-Wallis test. Pairwise comparisons were conducted using either LSD test or Wilcoxon test. The correlations between each parameter and BMD were examined using Pearson or Spearman correlation analysis. Receiver operating characteristic (ROC) curves were employed to evaluate the diagnostic efficacy of single and combined parameters for bone loss and osteoporosis.Results The differences in age, VBQ, VBQ-magic, T1av, T2av, and PDav values among the three groups were statistically significant (P<0.05). The VBQ-magic values for the normal bone group, bone loss group, and osteoporosis group were 2.92 (2.71, 3.11), 3.16 (2.87, 3.40), and 3.37 (3.19, 3.53), respectively, the differences between each pair of groups were statistically significant (P≤0.009). The T1av values were 622.80 (554.80, 692.00) ms, 565.40 (538.00, 599.20) ms, and 560.50 (515.80, 586.55) ms, respectively, the differences between the normal bone group and the bone loss group, as well as the osteoporosis group, were statistically significant (P=0.001 for both). The T2av values were (75.40±6.06) ms, (77.05±5.95) ms, and (84.79±5.36) ms, respectively, the differences among the normal bone group, bone loss group, and osteoporosis group were statistically significant (P<0.001 for both). The PDav value of the normal bone group was less than that of the bone loss group and osteoporosis group (P=0.007, 0.043). There was a moderate correlation between VBQ-magic, T1av, and BMD values (r=-0.524, 0.403), while T2av and PDav showed a weak correlation with BMD values (r=-0.365, -0.224). The areas under the curve (AUC) for VBQ-magic, T1av, and VBQ-magic+T1av in distinguishing bone loss were 0.772, 0.702, and 0.782, respectively. The diagnostic efficacy of VBQ-magic alone and combined with T1av showed no statistically significant difference from VBQ (P>0.05). The AUCs for VBQ-magic, T2av, and VBQ-magic+T2av in distinguishing osteoporosis were 0.810, 0.867, and 0.803, respectively. The diagnostic efficacy of VBQ-magic alone and combined with T2av showed no statistically significant difference from VBQ (P>0.05).Conclusions The VBQ scoring based on MAGiC T1-weighted images and the T1 and T2 values have a certain predictive ability for bone loss and osteoporosis, providing new diagnostic methods and reference indices for osteoporosis.
[Keywords] osteoporosis；vertebral bone quality；bone mineral densitym；agnetic resonance imaging；quantitative magnetic resonance imaging

WANG Wenjuan1, 3   ZOU Yuefen2*   HU Lei3   LIU Xiaofeng3   CHAI Liuyong3  

1 Nanjing Medical University, Nanjing 211166, China

2 Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

3 Department of Radiology, Chizhou People's Hospital, Chizhou 247100, China

Corresponding author: ZOU Y F, E-mail: zou_yf@163.com

Conflicts of interest   None.

Received  2024-01-04
Accepted  2024-03-22
DOI: 10.12015/issn.1674-8034.2024.04.016
Cite this article as: WANG W J, ZOU Y F, HU L, et al. Feasibility study of the MAGiC technique for quantitative assessment of primary osteoporosis[J]. Chin J Magn Reson Imaging, 2024, 15(4): 99-105. DOI:10.12015/issn.1674-8034.2024.04.016.

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