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• Clinical Article •
Comparison of brain functional alterations in type 2 diabetes mellitus based on resting-state functional magnetic resonance imaging indices
ZHANG Ge  ZHANG Yanwei  LIU Taiyuan  WANG Han  WEI Wei  WANG Meiyun 

Cite this article as ZHANG G, ZHANG Y W, LIU T Y, et al. Comparison of brain functional alterations in type 2 diabetes mellitus based on resting-state functional magnetic resonance imaging indices[J]. Chin J Magn Reson Imaging, 2024, 15(5): 8-12. DOI:10.12015/issn.1674-8034.2024.05.002.


[Abstract] Objective To explore the abnormal spontaneous neural activity in type 2 diabetes mellitus (T2DM) without cognitive impairment by combining multiple indices of resting-state functional magnetic resonance imaging (rs-fMRI).Materials and Methods Thirty-four T2DM patients without cognitive impairment and 34 age, sex and education matched control subjects were included in this study. Both groups received rs-fMRI scans in a 3.0 T MRI scanner. Amplitude of low frequency fluctuation(ALFF), regional homogeneity (ReHo) and voxel-mirrored homotopic connectivity (VMHC) were calculated after image preprocessing. Two sample t-test was performed to explore the abnormal alterations of brain function and the relationship among rs-fMRI indices and clinical characteristics was also investigated.Results T2DM patients showed decreased spontaneous neural activity in the left prefrontal cortex, right angular gyrus, while increased neural activity in the left caudate nucleus and supplementary motor area (GRF corrected, voxel P<0.001, cluster P<0.05). We also observed a decreased correlation between ALFF and ReHo in the prefrontal cortex and angular gyrus of T2DM (r=0.592-0.767, corrected P<0.05).Conclusions The application of multiple rs-fMRI indices detected abnormal neural activities in different brain regions of T2DM patients, and the decreased coupling trend between ALFF and could help to understand the early changes before cognitive impairment appeared.
[Keywords] type 2 diabetes mellitus；resting-state functional magnetic resonance imaging；magnetic resonance imaging；amplitude of low frequency fluctuation；regional homogeneity；voxel-mirrored homotopic connectivity

ZHANG Ge1, 2   ZHANG Yanwei2   LIU Taiyuan1   WANG Han2   WEI Wei1   WANG Meiyun1*  

1 Department of Radiology, Henan Provincial People's Hospital, Zhengzhou 450000, China

2 Department of Radiology, Bethune International Peace Hospital (980th Hospital of Joint Logistic Support Force), Shijiazhuang 050000, China

Corresponding author: WANG M Y, E-mail: mywang@zzu.edu.cn

Conflicts of interest   None.

Received  2023-12-18
Accepted  2024-04-30
DOI: 10.12015/issn.1674-8034.2024.05.002
Cite this article as ZHANG G, ZHANG Y W, LIU T Y, et al. Comparison of brain functional alterations in type 2 diabetes mellitus based on resting-state functional magnetic resonance imaging indices[J]. Chin J Magn Reson Imaging, 2024, 15(5): 8-12. DOI:10.12015/issn.1674-8034.2024.05.002.

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