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• Clinical Article •
A study on the degree centrality of patients of tension-type headache based on resting state functional magnetic resonance imaging
ZHANG Shuxian  GONG Ping  XU Qinyan  WANG Jili  WANG Xizhen  WANG Chao  SUN Xihe 

Cite this article as ZHANG S X, GONG P, XU Q Y, et al. A study on the degree centrality of patients of tension-type headache based on resting state functional magnetic resonance imaging[J]. Chin J Magn Reson Imaging, 2024, 15(5): 19-23. DOI:10.12015/issn.1674-8034.2024.05.004.


[Abstract] Objective To investigate the alterations in the centrality of whole brain network nodes of tension-type headache (TTH) patients in the slow-4 (0.027-0.073 Hz) band and slow-5 (0.010-0.027 Hz) band and the correlation with clinical features using resting state functional magnetic resonance imaging (rs-fMRI) with degree centrality (DC).Materials and Methods Thirty-three patients with TTH who went to the Department of Neurology of Affiliated Hospital of Weifang Medical University from May 2018 to July 2019 and 38 matched healthy controls were collected for resting state functional magnetic resonance scanning. The method of degree centrality was used to analyze the difference of DC values in different frequency bands between TTH group and healthy control group. The correlation between the abnormal DC value and Visual Analog Scale (VAS) score, disease duration and headache attack frequency of TTH patients was analyzed.Results Compared with the healthy control group, in the slow-5 (0.010-0.027 Hz) frequency band, the DC values of the right middle frontal gyrus and the right dorsolateral superior frontal gyrus of TTH patients were significantly increased; however, in the slow 4 (0.027-0.073 Hz) frequency band, there was no significant difference in DC value between TTH group and healthy control group (GRF correction, voxel level P<0.001, cluster level P<0.05). In addition, the results of correlation analysis showed that there was no significant correlation between abnormal DC brain regions and VAS scores, disease duration and headache attack frequency.Conclusions The middle frontal gyrus and superior frontal gyrus were involved in the integration and processing of pain signals, so they might be the key hub of TTH; the slow-5 frequency band was more sensitive in detecting the DC value of TTH than the slow-4 frequency band.
[Keywords] tension-type headache；degree centrality；resting state functional magnetic resonance imaging；magnetic resonance imaging；frequency dependent

ZHANG Shuxian1   GONG Ping1   XU Qinyan1   WANG Jili2   WANG Xizhen1   WANG Chao3*   SUN Xihe1*  

1 Medical Imaging Center, Affiliated Hospital of Weifang Medical University, Weifang 261031, China

2 Department of Medical Imaging, Shouguang City People's Hospital, Weifang 262700, China

3 Department of Basic Support, Affiliated Hospital of Weifang Medical University, Weifang 261031, China

Corresponding author: WANG C, E-mail: 63985634@qq.com SUN X H, E-mail: sunxihe8130@163.com

Conflicts of interest   None.

Received  2023-10-27
Accepted  2024-04-30
DOI: 10.12015/issn.1674-8034.2024.05.004
Cite this article as ZHANG S X, GONG P, XU Q Y, et al. A study on the degree centrality of patients of tension-type headache based on resting state functional magnetic resonance imaging[J]. Chin J Magn Reson Imaging, 2024, 15(5): 19-23. DOI:10.12015/issn.1674-8034.2024.05.004.

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