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• Clinical Article •
Prenatal MRI of fetal hippocampal infolding angle change in middle and third trimester
SUN Yue  CAO Yimin  YI Zexi  MENG Weixin  ZHOU Lixia 

Cite this article as SUN Y, CAO Y M, YI Z X, et al. Prenatal MRI of fetal hippocampal infolding angle change in middle and third trimester[J]. Chin J Magn Reson Imaging, 2024, 15(5): 24-27, 101. DOI:10.12015/issn.1674-8034.2024.05.005.


[Abstract] Objective Prenatal MRI was used to study the changes of the hippocampal infolding angle (HIA) of fetuses in the second and third trimester of pregnancy.Materials and Methods The imaging data of normal fetuses in the second and third trimester of pregnancy undergoing prenatal MRI in the Second Hospital of Hebei Medical University from January 2018 to December 2021 were collected and were retrospectively analyzed. HIA in the coronal section of fetal brain MRI using the fast imaging employing steady state acquisition (FIESTA) sequence was measured, the normal range of HIA in fetuses in the second and third trimester of pregnancy was analyzed, to explore its correlation with gestational age changes and clinical application value.Results A total of 139 cases of fetuses in the second and third trimester of pregnancy were included in the study, with a gestational age ranging from 20 to 38 weeks (mean 29.17±3.90 weeks), and a male-to-female ratio of 105∶34. The data was divided into 6 groups based on gestational age, and the confidence interval of fetal HIA was analyzed. With increasing gestational age, the HIA on both sides increased linearly (R2=0.803, 0.836, both P<0.001), and the HIA on the right side was greater than that on the left side. However, no gender differences were found in the left and right sides (P=0.898).Conclusions Prenatal MRI revealed that the changes of the HIA in fetuses in the second and third trimester of pregnancy follows a certain pattern, which can provide imaging diagnostic evidence for diseases related to hippocampal structural abnormalities either in utero or after birth.
[Keywords] fetus；hippocampal infolding angle；magnetic resonance imaging；development；hippocampal structure

SUN Yue   CAO Yimin   YI Zexi   MENG Weixin   ZHOU Lixia*  

Department of Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang 050051, China

Corresponding author: ZHOU L X, E-mail: doctorzhou@126.com

Conflicts of interest   None.

Received  2024-01-14
Accepted  2024-04-17
DOI: 10.12015/issn.1674-8034.2024.05.005
Cite this article as SUN Y, CAO Y M, YI Z X, et al. Prenatal MRI of fetal hippocampal infolding angle change in middle and third trimester[J]. Chin J Magn Reson Imaging, 2024, 15(5): 24-27, 101. DOI:10.12015/issn.1674-8034.2024.05.005.

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