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• Clinical Article •
Prognostic factors analysis of acute anterior circulation ischemic stroke with drug treatment based on TASL technology
LI Xiaolei  SHAN Chunhui  ZHAO Mingjuan  ZHANG Hui  BAO Yunfeng  CHEN Yingmin 

Cite this article as LI X L SHAN C H, ZHAO M J, et al. Prognostic factors analysis of acute anterior circulation ischemic stroke with drug treatment based on TASL technology[J]. Chin J Magn Reson Imaging, 2024, 15(5): 28-33. DOI:10.12015/issn.1674-8034.2024.05.006.


[Abstract] Objective To explore the impact of prognostic factors of acute anterior circulation ischemic stroke (AACIS) after conservative drug treatment based on territorial arterial spin labeling (TASL) technology.Materials and Methods Retrospectively, a total of 136 patients with confirmed AACIS were consecutively collected and divided into two groups:good prognosis (70 cases) and poor prognosis (66 cases) according to their prognosis after 90 d treatment. The degree of stenosis of the responsible vessel, territorial cerebral blood flow (TCBF) before treatment, TCBF10 d after treatment, relative CBF (rTCBF) and the lesion volume were recorded. Simultaneously, baseline national institute of health stroke scale (NIHSS), age, gender, stroke classification, body mass index and other risk factor information from patients were collected. Incorporate the above indicators into the statistical model. The measurement data between the two groups were analyzed using Mann Whitney U test, and the counting data were analyzed using χ2test for univariate differences. Multivariate joint logistic regression analysis was performed on statistically significant indicators, and receiver operating characteristic curve (ROC) was used to evaluate the diagnostic efficacy of the results.Results In univariate analysis, there were significant differences in age (Z=16.022), baseline NIHSS score (Z=148.400), stroke classification (Z=49.640), responsible vessel stenosis (Z=27.193), baseline TCBFpre-treatment (Z=693.000), rTCBF (Z=18.874) and lesion volume (Z=-10.140) between the two groups (P<0.05). In multivariate joint analysis, age (OR=0.108), baseline NIHSS score (OR=0.615), perforating artery disease of stroke classification (OR=90.154), TCBFpre-treatment (OR=4.611) and lesion volume (OR=0.138) had significant impact on prognosis (P<0.05). The combination of the four methods for predicting prognosis was effective (P<0.05), and the area under the ROC curve was 0.962, which has high value. The changes in responsible vascular perfusion have no significant impact on prognosis (P>0.05).Conclusions With drug conservative treatment, the 90 d prognosis of patients was more likely to be affected by age, baseline NIHSS, stroke classification, TCBFpre-treatment and lesion volume, but not related to the improvement of responsible vascular perfusion.
[Keywords] acute anterior circulation ischemic stroke；drug conservative treatment；magnetic resonance imaging；territorial arterial spin labeling；cerebral blood flow

LI Xiaolei1   SHAN Chunhui2*   ZHAO Mingjuan2   ZHANG Hui2   BAO Yunfeng2   CHEN Yingmin2  

1 Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang 050000, China

2 Department of Medical Imaging, Hebei Province General Hospital, Shijiazhuang 050051, China

Corresponding author: SHAN C H, E-mail: 89557220@qq.com

Conflicts of interest   None.

Received  2023-11-20
Accepted  2024-04-17
DOI: 10.12015/issn.1674-8034.2024.05.006
Cite this article as LI X L SHAN C H, ZHAO M J, et al. Prognostic factors analysis of acute anterior circulation ischemic stroke with drug treatment based on TASL technology[J]. Chin J Magn Reson Imaging, 2024, 15(5): 28-33. DOI:10.12015/issn.1674-8034.2024.05.006.

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