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• Clinical Article •
Individual-based morphological brain network and its association with acute mild traumatic brain injury
YAN Jiahao  HUANG Wenjing  WANG Jun  LI Yan  XIONG Diaohan  ZHANG Jing 

Cite this article as YAN J H, HUANG W J, WANG J, et al. Individual‐based morphological brain network and its association with acute mild traumatic brain injury[J]. Chin J Magn Reson Imaging, 2024, 15(5): 55-60. DOI:10.12015/issn.1674-8034.2024.05.010.


[Abstract] Objective To explore the changes of individual-based morphological brain network topological properties in patients with mild traumatic brain injury (mTBI).Materials and Methods A sample of 43 mTBI patients and 37 healthy controls (HC) were included. After T1WI data of all subjects were collected, using the Freesurfer to do data preprocessing and geting severals morphological indices (cortical thickness, gray matter volume, brain surface area, sulcus depth, mean curvature), which construct the individual-based morphological brain network, and then Graph Theoretical Network Analysis (GRETNA) was utilized to calculate the network topological properties. The last, differences between the two groups were compared based on two-samples t-test, with false discovery rate (FDR) corrections for multiple comparisons.Results Compared with the HC group, the mTBI group showed approximately differences in nodal degree centrality (DC), the brain regions of left frontal pole transverse gyrus (t=-2.186, P=0.032), central sulcus (t=-2.617, P=0.011), horizontal anterior segment of lateral fissure (t=-2.456, P=0.016) and right pole occipital (t=-2.013, P=0.048) were increased, and nodal efficiency (Ne) of left frontal pole transverse gyrus (t=-2.182, P=0.032;), central sulcus (t=-2.226, P=0.029), horizontal anterior segment of lateral fissure (t=-2.440, P=0.017) and right precuneus (t=-2.207, P=0.030) were increased, which were related to cognitive and executive functions; in addition, the memory and emotional regulation cortexs suffered biggest drop, the DC of the nodes in the left cuneus (t=2.173, P=0.033), angular return (t=2.498, P=0.015) and parahippocampal gyrus (t=4.009, P<0.001) were dropped, and Ne in the left planum polare of the superior temporal gyrus (t=2.394, P=0.019), angular return (t=2.668, P=0.009), parahippocampal gyrus (t=4.671, P<0.001), callosal sulcus (t=2.189, P=0.032) were dropped. The global topological properties differences were not statistically significant (P>0.05).Conclusions The individual morphological brain network of mTBI in the acute phase still retains the small-world attribute. The abnormally elevated nodes DC and Ne of mTBI are mainly concentrated in brain regions related to cognitive and executive functions, reflecting the brain's stress compensation for cognitive functions. The abnormally reduced nodes DC and Ne, mainly concentrated in brain regions related to memory and emotion regulation, revealed cognitive and emotional changes in the acute phase. This provides a new perspective for the study of mTBI in the acute phase and provides further clues for the exploration of the mechanism of brain network alteration.
[Keywords] mild traumatic brain injury；structural magnetic resonance imaging；magnetic resonance imaging；morphological brain network；graph theory analysis

YAN Jiahao1, 2, 3   HUANG Wenjing1, 2, 3   WANG Jun1, 2, 3   LI Yan4   XIONG Diaohan1, 2, 3   ZHANG Jing1, 2, 3*  

1 Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou 730030, China

2 Second Clinical School, Lanzhou University, Lanzhou 730000, China

3 Gansu Province Clinical Research Center for Functional and Molecular Imaging, Lanzhou 730030, China

4 Mathematics and Statistics School, Lanzhou University, Lanzhou 730000, China

Corresponding author: ZHANG J, E-mail: lztong2001@163.com

Conflicts of interest   None.

Received  2023-08-23
Accepted  2024-03-04
DOI: 10.12015/issn.1674-8034.2024.05.010
Cite this article as YAN J H, HUANG W J, WANG J, et al. Individual‐based morphological brain network and its association with acute mild traumatic brain injury[J]. Chin J Magn Reson Imaging, 2024, 15(5): 55-60. DOI:10.12015/issn.1674-8034.2024.05.010.

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