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• Clinical Article •
Application of ADC values to assess inflammatory lymph nodes in the drainage area of the salivary glands of patients with primary Sjogren's syndrome
TIAN Manting  DING Changwei 

Cite this article as TIAN M T, DING C W. Application of ADC values to assess inflammatory lymph nodes in the drainage area of the salivary glands of patients with primary Sjogren's syndrome[J]. Chin J Magn Reson Imaging, 2024, 15(5): 68-74. DOI:10.12015/issn.1674-8034.2024.05.012.


[Abstract] Objective To investigate the apparent diffusion coefficient (ADC) and morphology of lymph nodes in the drainage area of salivary glands among patients with primary Sjögren's syndrome (pSS) before and after treatment and healthy volunteer, and its potential in reflecting the degree of inflammatory activity of the disease in patients with pSS.Materials and Methods A total of 23 patients with pSS were collected to undergo routine head and neck MRI and diffusion weighted imaging (DWI) before and after 12 weeks of regular treatment, respectively. ADC images were obtained after post-processing. Then 15 healthy volunteers were collected as controls during the same period. Using t-test to compare the morphology and ADC values of the lymph nodes in each level among the pSS patients before and after treatment, and healthy volunteers.Results The short diameters of lymph nodes in level Ⅰb, Ⅱa, and Ⅱb in patients with pSS before treatment were larger than those of healthy volunteers [Ⅰb (t=2.293, P=0.028), Ⅱa (t=2.397, P=0.022), Ⅱb (t=1.409, P=0.030)] , and the short diameters of lymph nodes in all salivary gland drainage levels were smaller after 12 weeks of treatment [Ⅰa (t=4.391, P<0.001), Ⅰb (t=3.439, P=0.002), Ⅱa (t=3.458, P=0.002), Ⅱb (t=4.667, P=0.001)]. ADC values of lymph nodes in level Ⅰb and Ⅱa in pSS patients before treatment were smaller than those of healthy volunteers [Ⅰb (t=3.337, P=0.002), Ⅱa (t=2.207, P=0.038)] , and they became larger than those of lymph nodes in level Ⅰa, Ⅰb, and Ⅱa after 12 weeks of treatment [Ⅰa (t=3.674, P=0.001), Ⅰb (t=2.198, P=0.039), Ⅱa (t=2.484, P=0.004)].Conclusions The short diameters of lymph nodes in level Ⅰb, Ⅱa and Ⅱb may be of great value in identifying patients with pSS and healthy volunteers, and the short diameters of lymph nodes in all levels may be of great value in identifying patients with pSS before and after treatment; the ADC values of lymph nodes in level Ⅰb and Ⅱa may be of great value in identifying patients with pSS and healthy volunteers, and the ADC values of lymph nodes in level Ia, Ⅰb and Ⅱa may be of great value in identifying patients with pSS before and after treatment.
[Keywords] autoimmune disease；primary Sjögren's syndrome；inflammatory activity of the disease；diffusion weighted imaging；apparent diffusion coefficient；magnetic resonance imaging

TIAN Manting   DING Changwei*  

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, China

Corresponding author: DING C W, E-mail: 18940254003@163.com

Conflicts of interest   None.

Received  2024-01-06
Accepted  2024-04-23
DOI: 10.12015/issn.1674-8034.2024.05.012
Cite this article as TIAN M T, DING C W. Application of ADC values to assess inflammatory lymph nodes in the drainage area of the salivary glands of patients with primary Sjogren's syndrome[J]. Chin J Magn Reson Imaging, 2024, 15(5): 68-74. DOI:10.12015/issn.1674-8034.2024.05.012.

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