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• Clinical Article •
Diagnostic and short-term follow-up value of multi-parameter cardiac magnetic resonance in young children with acute myocarditis
FENG Zhanqi  SHANG Honglei  LIAO Junjie  YIN Xing  SHEN Yanyong  LU Yu  LI Sike  ZHANG Xiaoxue  WANG Changhao  ZHAO Xin 

Cite this article as FENG Z Q, SHANG H L, LIAO J J, et al. Diagnostic and short-term follow-up value of multi-parameter cardiac magnetic resonance in young children with acute myocarditis[J]. Chin J Magn Reson Imaging, 2024, 15(5): 126-133. DOI:10.12015/issn.1674-8034.2024.05.020.


[Abstract] Objective To explore the value of multi-parameter cardiac magnetic resonance (CMR) in the diagnosis and short-term follow-up of acute myocarditis in young children.Materials and Methods A total of 60 children with acute myocarditis under eight years old and 30 children in the control group who attended our hospital from January 2022 to February 2024 were prospectively analyzed. Clinical information and CMR data [including native T1 value, extracellular volume fraction (ECV), T2 value, T2 signal ratio, and late gadolinium enhancement (LGE) of the left ventricle myocardium] of all subjects were collected. The diagnostic efficacy of single and combined parameters was evaluated using the receiver operating characteristic (ROC) curve, and the area under the curve (AUC), sensitivity, specificity, and accuracy were calculated. The paired test was used to compare the CMR data of young children with acute myocarditis at initial diagnosis and follow-up.Results The native T1 value, ECV value, T2 value, T2 signal ratio, and LGE-positive cases were significantly higher in the acute myocarditis group than in the control group (all P<0.001). The optimal cut-off values of the native T1 value, ECV value, T2 value, and T2 signal ratio were 1 232.50 ms, 30.50%, 53.50 ms, and 1.75, respectively. The AUCs of the native T1 value, T2 value, and T2 signal ratio (0.917, 0.889 and 0.839, respectively) were higher than those of other single parameters, but there was no significant difference between the three parameters (all P>0.05), with the native T1 value having the highest sensitivity and accuracy of 81.7% and 83.3%, respectively. The AUCs of the 2018 Lake Louise Criteria (LLC), the 2018LLC excluding ECV, and the native T1 value combined with the T2 value (0.933, 0.917 and 0.892, respectively) were higher than other combined parameters, but there was no significant difference between the three parameters (all P>0.05), with 2018LLC having the highest sensitivity and accuracy of 90.0% and 92.2%, respectively. Compared with the initial diagnosis, the native T1 value, ECV value, T2 value, T2 signal ratio, the number of myocardial segments involved in LGE, and the number of cases consistent with 2018LLC were overall lower at short-term follow-up (all P<0.05).Conclusions Multi-parameter CMR can be used as an effective method to diagnose acute myocarditis in young children and monitor the changes in children's condition after treatment during the short-term follow-up.
[Keywords] acute myocarditis；children；diagnosis；follow-up；cardiac magnetic resonance；Lake Louise Criteria；magnetic resonance imaging

FENG Zhanqi   SHANG Honglei   LIAO Junjie   YIN Xing   SHEN Yanyong   LU Yu   LI Sike   ZHANG Xiaoxue   WANG Changhao   ZHAO Xin*  

Department of Medical Imaging, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

Corresponding author: ZHAO X, E-mail: zdsfyzx@zzu.edu.cn

Conflicts of interest   None.

Received  2024-01-28
Accepted  2024-04-29
DOI: 10.12015/issn.1674-8034.2024.05.020
Cite this article as FENG Z Q, SHANG H L, LIAO J J, et al. Diagnostic and short-term follow-up value of multi-parameter cardiac magnetic resonance in young children with acute myocarditis[J]. Chin J Magn Reson Imaging, 2024, 15(5): 126-133. DOI:10.12015/issn.1674-8034.2024.05.020.

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