Research progress of magnetic resonance 3D-TIWI and diffusion imaging in Alzheimer<sup><sup>,</sup></sup>s disease

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Research progress of magnetic resonance 3D-TIWI and diffusion imaging in Alzheimer's disease

LI Linqin DUAN Huanqin QIU Lihua

Cite this article as LI L Q, DUAN H Q, QIU L H. Research progress of magnetic resonance 3D-TIWI and diffusion imaging in Alzheimer's disease[J]. Chin J Magn Reson Imaging, 2024, 15(5): 181-186. DOI:10.12015/issn.1674-8034.2024.05.029.

Abstract

[Abstract] Alzheimer's disease (AD) is the most common neurodegenerative disease. The main symptoms are progressive memory decline and cognitive dysfunction. The incidence rate is on the rise, and there is a lack of effective treatment. Therefore, early diagnosis, prevention and delay of AD are essential. In recent years, MRI has been widely used in the study of AD and other cognitive impairment fields. Three-dimensional T1 weighted imaging (3D-T1WI), diffusion MRI can objectively and indirectly reflect abnormal brain structural changes, providing imaging evidence for explaining their mechanisms. This article provides a review of the application of 3D-T1WI, diffusion MRI in AD, exploring the changes in brain structure and pathophysiological mechanisms of AD patient from multiple perspectives, and providing assistance for the early diagnosis of AD.

[Keywords] Alzheimer's disease；magnetic resonance imaging；three-dimensional T1 weighted imaging；diffusion tensor imaging；diffusion kurtosis imaging；neurite direction dispersion and density imaging；brain structure；pathophysiological mechanism；early diagnosis

Contributor Information

LI Linqin^{1,
2}   DUAN Huanqin^{2,
3}   QIU Lihua^{1,
2,
4*}

¹ School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China

² Medical Imaging Center, Second People's Hospital of Yibin, Yibin 644000, China

³ Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China

⁴ Clinical Medical Research and Transformation Center, the Second People's Hospital of Yibin City-West China Yibin Hospital, Sichuan Univerity, Neuroimaging Big Data Research Center, Yibin 644000, China

Corresponding author: QIU L H, E-mail: qlh20050616@foxmail.com

Conflicts of interest None.

Publication Information

Received 2024-01-20

Accepted 2024-04-30

DOI: 10.12015/issn.1674-8034.2024.05.029

Text

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