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• Clinical Article •
Abnormal cortical thickness and functional connectivity of the left insula and right posterior parietal cortex in Crohn's disease
ZHENG Yanling  LI Yunfei  HU Yang  RONG Lan  ZHOU Yan  LIANG Zonghui 

Cite this article as: ZHENG Y L, LI Y F, HU Y, et al. Abnormal cortical thickness and functional connectivity of the left insula and right posterior parietal cortex in Crohn's disease[J]. Chin J Magn Reson Imaging, 2024, 15(6): 31-35. DOI:10.12015/issn.1674-8034.2024.06.004.


[Abstract] Objective To investigate the alterations in brain structure and function among patients with Crohn's disease (CD) and their correlation with clinical indicators.Materials and Methods Brain structural and resting-state functional magnetic resonance imaging data, along with clinical indicator data, were collected from 20 CD patients and 21 healthy controls. Based on the Schaefer atlas, the left and right hemispheres were divided into 100 brain regions, and the differences in cortical thickness between the two groups were examined. Functional connectivity (FC) was calculated among the brain regions showing significant structural group difference, and the differences in FC between the two groups were compared. The associations between clinical indicators [Self-rating Anxiety Scale (SAS) score, Self-rating Depression Scale (SDS) score, CD activity index and disease duration] and abnormal cortical thickness & FC were measured using Pearson correlation coefficient in CD group.Results Compared to the healthy control group, CD patients exhibited a decrease in cortical thickness in the left insula (P=0.002, FDR correction) and right posterior parietal cortex (P=0.031, FDR correction). The FC between the left insula and right posterior parietal cortex was significantly reduced in CD group (P=0.025). Furthermore, there was a significant negative correlation between cortical thickness of left insula and SDS score among CD patients (r=-0.61, P=0.007).Conclusions The left insular and right posterior parietal cortex structure and FC are damaged in CD patients compared with normal controls. The thickness of left insular cortex is associated with the increase of depression score, which provides new clues for understanding the neural mechanism of CD.
[Keywords] Crohn's disease；neural mechanism；functional magnetic resonance imaging；structural magnetic resonance imaging；magnetic resonance imaging

ZHENG Yanling1   LI Yunfei2   HU Yang3   RONG Lan4   ZHOU Yan5   LIANG Zonghui1*  

1 Department of Radiology, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai 200040, China

2 Department of Radiology, the Fifth People's Hospital of Shanghai,Fudan University, Shanghai 200240, China

3 Bi-Liang Brain Imaging Group, Liangjiang New Area, Chongqing 401120, China

4 Department of Gastroenterology, Huashan Hospital, Fudan University, Shanghai 200040, China

5 Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China

Corresponding author: LIANG Z H, E-mail: liangzh@vip.163.com

Conflicts of interest   None.

Received  2024-02-26
Accepted  2024-05-14
DOI: 10.12015/issn.1674-8034.2024.06.004
Cite this article as: ZHENG Y L, LI Y F, HU Y, et al. Abnormal cortical thickness and functional connectivity of the left insula and right posterior parietal cortex in Crohn's disease[J]. Chin J Magn Reson Imaging, 2024, 15(6): 31-35. DOI:10.12015/issn.1674-8034.2024.06.004.

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