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• Clinical Article •
Predictive value of cerebral blood tubule burden score for recurrent cerebrovascular events in patients with transient ischemic attack
JIANG Yanliu  WANG Shupei  LI Feng  ZHANG Lu 

Cite this article as: JIANG Y L, WANG S P, LI F, et al. Predictive value of cerebral blood tubule burden score for recurrent cerebrovascular events in patients with transient ischemic attack[J]. Chin J Magn Reson Imaging, 2024, 15(6): 67-71. DOI:10.12015/issn.1674-8034.2024.06.010.


[Abstract] Objective To investigate the predictive value of CSVD burden score for recurrent cerebrovascular events (RCVEs) in patients with transient ischemic attack (TIA).Materials and Methods A total of 182 patients with TIA who were treated in the Second People's Hospital of Anhui Province from October 2019 to December 2022 were selected as the research objects. The overall burden score of CSVD was calculated according to MRI examination. According to the presence or absence of RCVEs within 1 month of follow-up, they were divided into RCVEs group (n=46) and non-RCVEs group (n=136). The clinical data and CSVD total burden score were compared between the two groups. Multivariate logistic regression analysis model was used to analyze the independent risk factors of RCVEs. The receiver operating characteristic (ROC) curve was drawn to analyze the predictive value of CSVD image feature score and total burden score for RCVEs in TIA patients.Results There were significant differences in the number of TIA attacks, duration of symptoms, history of hypertension, total burden score and classification of CSVD between the RCVEs group and the non-RCVEs group (P<0.05). Multivariate Logistic regression analysis showed that the number of TIA attacks, the duration of symptoms, and the total burden score of CSVD were independent risk factors for RCVEs in TIA patients (P<0.05). The results of ROC curve analysis showed that the areas under curve (AUC) of CSVD imaging marker score and total burden score in predicting RCVEs in TIA patients were 0.771 (95% CI: 0.673-0.869, P<0.001), 0.745 (95% CI: 0.655-0.835, P<0.001), 0.664 (95% CI: 0.549-0.780, P=0.009), 0.845 (95% CI: 0.766-0.924, P<0.001), 0.945 (95% CI: 0.896-0.994, P<0.001), respectively. The AUC predicted by CVSD total burden score was the highest. When the optimal cutoff value was 2 points, the sensitivity was 86.05% and the specificity was 83.02%.Conclusions The CSVD total burden score has a good predictive value for RCVEs in TIA patients, which is helpful for clinical evaluation of short-term prognosis in TIA patients.
[Keywords] transient ischemic attack；cerebral small vessel disease；magnetic resonance imaging；cerebral vascular burden score；recurrent cerebrovascular events；prognosis

JIANG Yanliu*   WANG Shupei   LI Feng   ZHANG Lu  

Department of Neurologic, Anhui Second People's Hospital, Hefei 230041, China

Corresponding author: JIANG Y L, E-mail: jiangyanliu66@163.com

Conflicts of interest   None.

Received  2023-10-20
Accepted  2024-05-10
DOI: 10.12015/issn.1674-8034.2024.06.010
Cite this article as: JIANG Y L, WANG S P, LI F, et al. Predictive value of cerebral blood tubule burden score for recurrent cerebrovascular events in patients with transient ischemic attack[J]. Chin J Magn Reson Imaging, 2024, 15(6): 67-71. DOI:10.12015/issn.1674-8034.2024.06.010.

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