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• Clinical Article •
Value of cardiac magnetic resonance feature tracking in the evaluation of patients with pulmonary hypertension due to left heart failure
JIA Han  QIAN Wen  ZHU Xiaomei  ZHOU Yanli  XU Yi  ZHU Yinsu 

Cite this article as: JIA H, QIAN W, ZHU X M, et al. Value of cardiac magnetic resonance feature tracking in the evaluation of patients with pulmonary hypertension due to left heart failure[J]. Chin J Magn Reson Imaging, 2024, 15(6): 72-78, 93. DOI:10.12015/issn.1674-8034.2024.06.011.


[Abstract] Objective To quantitatively evaluate the myocardial strain by cardiac magnetic resonance feature tracking (CMR-FT) and investigate the value of cardiac magnetic resonance (CMR) parameters of patients with pulmonary hypertension due to left heart failure (PH-LHF).Materials and Methods The clinical and CMR data of 215 patients with left heart failure (LHF) hospitalized between September 2018 and September 2020 were retrospectively analyzed, and they were divided into two groups, 129 patients with LHF and 86 patients with PH-LHF according to systolic pulmonary artery pressure (sPAP) measured by echocardiography. The baseline data and CMR parameters, including biventricular related volumetric and functional parameters, structural parameters and myocardial strain parameters were statistically analyzed. Univariate and multivariate logistic regression analysis were used to analyze the independent predictors of PH-LHF, and receiver operating characteristics (ROC) curves were plotted to evaluate the diagnostic value of CMR parameters.Results In patients with PH-LHF, left ventricular (LV) and right ventricular (RV) end diastolic volume index (EDVI), end systolic volume index (ESVI), right ventricular myocardial mass index (RVMMI), ventricular septal angle as well as left atrial structural parameters, including maximum of left atrial diameter (LADmax) and maximum of left atrial area (LA-amax) were higher than those in patients with LHF, while LV and RV ejection fraction (EF), right ventricular stroke volume index (RVSVI), right ventricular cardiac index (RVCI) were lower than those in patiets with LHF. LV global longitudinal strain (GLS), global circumferential strain (GCS) and the corresponding rate, RV GCS, left atrial active strain (εa), left atrial passive strain (εe), left atrial total strain (εs) were all decreased in patients with PH-LHF. Multivariate logistic regression analysis showed that RVEF, LV GCS, εa and LADmax were independent predictors of PH-LHF. ROC analysis showed that the AUC values of the clinical model, CMR model and combined model were 0.773, 0.777 and 0.828, respectively. The DeLong test showed that the diagnostic performance of the clinical model was improved after the addition of CMR parameters (0.773 vs. 0.828, P<0.05).Conclusions CMR-FT can quantitatively evaluate biventricular and left atrial strain, and reflect myocardial function in patients with PH-LHF. CMR has a certain clinical value in the assessment of patients with PH-LHF.
[Keywords] left heart failure；pulmonry hypertension；diagnostic value；cardiac magnetic resonance feature tracking；left ventricular strain；left atrial strain；magnetic resonance imaging

JIA Han1   QIAN Wen1   ZHU Xiaomei1   ZHOU Yanli1   XU Yi1   ZHU Yinsu2*  

1 Department of Radiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

2 CT Room of Imaging Center, the Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China

Corresponding author: ZHU Y S, E-mail: zhuyinsu@njmu.edu.cn

Conflicts of interest   None.

Received  2024-01-18
Accepted  2024-05-13
DOI: 10.12015/issn.1674-8034.2024.06.011
Cite this article as: JIA H, QIAN W, ZHU X M, et al. Value of cardiac magnetic resonance feature tracking in the evaluation of patients with pulmonary hypertension due to left heart failure[J]. Chin J Magn Reson Imaging, 2024, 15(6): 72-78, 93. DOI:10.12015/issn.1674-8034.2024.06.011.

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