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Research progress in PET/MR for diagnosis of Alzheimer's disease within ATN framework
ZHOU Yan  ZHOU Qidong  YIN Chenru  WU Ruolin  GAI Yongkang  SU Ying  XIA Xiaotian 

Cite this article as: ZHOU Y, ZHOU Q D, YIN C R, et al. Research progress in PET/MR for diagnosis of Alzheimer's disease within ATN framework[J]. Chin J Magn Reson Imaging, 2024, 15(6): 159-165. DOI:10.12015/issn.1674-8034.2024.06.025.


[Abstract] Alzheimer's disease (AD), a leading cause of dementia, emphasizes the critical importance of early diagnosis for timely intervention and disease progression mitigation. In 2018, the National Institute of Aging and Alzheimer's Association (NIA-AA) introduced the ATN (amyloid/tau/neurodegeneration) diagnostic criteria for AD, which has garnered extensive clinical acceptance and utilization. This article offers a comprehensive review of the applications of positron emission tomography (PET), magnetic resonance imaging (MRI), and integrated positron emission tomography-magnetic resonance imaging (PET/MR) in the ATN diagnostic framework, and explores the profound advantages of multi-probe, multi-modal PET/MR in diagnosis. The objective is to provide researchers with novel perspectives and references for further investigation, drive the clinical application of PET/MR for AD patients, and furnish clinicians with crucial imaging evidence to support their practice
[Keywords] Alzheimer's disease；biomarkers；positron emission tomography；magnetic resonance imaging；multimodal imaging

ZHOU Yan1   ZHOU Qidong2#   YIN Chenru3   WU Ruolin1   GAI Yongkang1   SU Ying2*   XIA Xiaotian1*  

1 Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province Key Laboratory of Molecular Imaging, Key Laboratory of Biological Targeted Therapy, the Ministry of Education, Wuhan 430022, China

2 Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

3 Hubei Academy of Scientific and Technical Information, Wuhan 430070, China

Corresponding author: SU Y, E-mail: suying0110@126.com XIA X T, E-mail: xiaotian_xia@hust.edu.cn

Conflicts of interest   None.

Received  2024-02-04
Accepted  2024-06-03
DOI: 10.12015/issn.1674-8034.2024.06.025
Cite this article as: ZHOU Y, ZHOU Q D, YIN C R, et al. Research progress in PET/MR for diagnosis of Alzheimer's disease within ATN framework[J]. Chin J Magn Reson Imaging, 2024, 15(6): 159-165. DOI:10.12015/issn.1674-8034.2024.06.025.

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