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• Clinical Article •
Impact of regulating amygdala activity in patients with insomnia disorders using rtfMRI-NF technology on the centrality of the brain
GU Yuang  ZHANG Miao  JIA Shulei  SUN Yongbing  QI Fei  WU Xiaoling  ZOU Zhi  LI Zhonglin  ZHOU Jing  DOU Shewei  YAN Fengshan  LI Yongli 

Cite this article as: GU Y A, ZHANG M, JIA S L, et al. Impact of regulating amygdala activity in patients with insomnia disorders using rtfMRI-NF technology on the centrality of the brain[J]. Chin J Magn Reson Imaging, 2024, 15(7): 64-69. DOI:10.12015/issn.1674-8034.2024.07.011.


[Abstract] Objective To investigate the effect of real-time functional magnetic resonance imaging neurofeedback (rtfMRI-NF) on the modulation of amygdala activity and its impact on the degree centrality (DC) in the brains of patients with insomnia disorder (ID).Materials and Methods The study applied rtfMRI-NF to modulate the amygdala activity of 34 ID patients, assessing the effects before and after treatment using Polysomnography (PSG) and the Pittsburgh Sleep Quality Index (PSQI). Paired t-tests were used to analyze the differences in DC values of brain regions before and after the intervention, exploring the changes in DC values and their correlations with clinical scale data.Results After rtfMRI-NF modulation, significant reductions were observed in the PSQI scores and Insomnia Severity Index (ISI) among ID patients (P<0.05 for both). Furthermore, an increase in the DC value of the right parahippocampal gyrus was noted (GRF corrected, voxel-level P<0.001, cluster-level P<0.05), which negatively correlated with the change in sleep efficiency (r=-0.478, P<0.05); Conversely, a decrease in the DC value of areas such as the right dorsolateral prefrontal cortex was observed (GRF corrected, voxel-level P<0.001, cluster-level P<0.05), positively correlating with the post-intervention ISI scores (r =0.488, P<0.05).Conclusions rtfMRI-NF can reshape the DC values of specific brain regions in ID patients and effectively improve their sleep quality.
[Keywords] insomnia disorder；real-time functional magnetic resonance imaging neurofeedback；magnetic resonance imaging；resting-state functional magnetic resonance imaging；amygdala；degree centrality

GU Yuang1   ZHANG Miao2   JIA Shulei1   SUN Yongbing2   QI Fei3   WU Xiaoling4   ZOU Zhi3   LI Zhonglin3   ZHOU Jing5   DOU Shewei3   YAN Fengshan3   LI Yongli5*  

1 Xinxiang Medical University Henan Provincial People's Hospital, Xinxiang 453003, China

2 Zhengzhou University People's Hospital, Zhengzhou 450003, China

3 Department of Medical Imaging, Henan Provincial People's Hospital, Zhengzhou 450003, China

4 Department of Nuclear Medicine, Henan Provincial People's Hospital/People's Hospital of Zhengzhou University, Zhengzhou 450003, China

5 Department of Health Management, People's Hospital of Zhengzhou University/Henan Provincial People's Hospital, Zhengzhou 450003, China

Corresponding author: LI Y L, E-mail: shyliyongli@126.com

Conflicts of interest   None.

Received  2024-03-30
Accepted  2024-06-25
DOI: 10.12015/issn.1674-8034.2024.07.011
Cite this article as: GU Y A, ZHANG M, JIA S L, et al. Impact of regulating amygdala activity in patients with insomnia disorders using rtfMRI-NF technology on the centrality of the brain[J]. Chin J Magn Reson Imaging, 2024, 15(7): 64-69. DOI:10.12015/issn.1674-8034.2024.07.011.

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