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• Clinical Article •
Meta analysis of the diagnostic value of carotid artery high-resolution magnetic resonance vessel wall imaging in the occurrence and recurrence of ischemic stroke
LUO Tong  GAO Yang  WU Qiong  HE Jinlong  WANG Zehua 

Cite this article as: LUO T, GAO Y, WU Q, et al. Meta analysis of the diagnostic value of carotid artery high-resolution magnetic resonance vessel wall imaging in the occurrence and recurrence of ischemic stroke[J]. Chin J Magn Reson Imaging, 2024, 15(7): 70-75. DOI:10.12015/issn.1674-8034.2024.07.012.


[Abstract] Objective To analyze the diagnostic value of high-resolution magnetic resonance vascular wall imaging (HR-VWI) of the carotid artery for the occurrence and recurrence of ischemic stroke based on Meta.Materials and Methods Retrieve relevant studies on HR-VWI assessment of ischemic stroke occurrence and recurrence published in Web of Science, Embase, The Cochrane Library, Medline, PubMed, China National Knowledge Network, Wanfang, and VIP database, with a search period from database establishment to February 2024. Select literature based on inclusion and exclusion criteria. Use a fixed effects model to calculate and combine the odds ratio (OR) or hazard ratio (HR) of different vulnerable carotid plaque features, and conduct meta-analysis using Stata 17.0 and RevMan 5.6.Results Seventeen articles met the inclusion criteria. In 8 retrospective studies, intraplaque hemorrhage (OR=1.92, 95% CI: 1.46-2.52), lipid-rich necrotic nucleus (OR=2.78, 95% CI: 1.84-4.18), plaque calcification (OR=1.26, 95% CI: 0.99-1.61) and fibrous cap rupture (OR=1.64, 95% CI: 1.06-2.52) were significantly associated with ischemic stroke. In nine prospective studies, intraplaque hemorrhage (HR=6.88, 95% CI: 4.46-10.61), lipid-rich necrotic nucleus (HR=1.78, 95% CI: 0.87-3.65), fibrous cap rupture (HR=3.01, 95% CI: 1.53-5.93) were significantly associated with ischemic stroke recurrence.Conclusions HR-VWI can accurately evaluate the characteristics of carotid artery plaque components, which are significantly related with the occurrence and recurrence of ischemic stroke. Due to the lack of original research, a large sample size cohort study of carotid plaque is needed in the future to further provide timely accurate prediction of the occurrence and recurrence of ischemic stroke and guide clinical treatment by assessing the characteristics of carotid atherosclerotic plaque.
[Keywords] stroke；stroke recurrence；magnetic resonance imaging；vascular wall imaging；vulnerable plaque；Meta analysis

LUO Tong   GAO Yang*   WU Qiong   HE Jinlong   WANG Zehua  

Department of Imaging Diagnosis, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China

Corresponding author: GAO Y, E-mail: 1390903990@qq.com

Conflicts of interest   None.

Received  2024-02-26
Accepted  2024-07-06
DOI: 10.12015/issn.1674-8034.2024.07.012
Cite this article as: LUO T, GAO Y, WU Q, et al. Meta analysis of the diagnostic value of carotid artery high-resolution magnetic resonance vessel wall imaging in the occurrence and recurrence of ischemic stroke[J]. Chin J Magn Reson Imaging, 2024, 15(7): 70-75. DOI:10.12015/issn.1674-8034.2024.07.012.

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