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• Clinical Article •
Diffusion kurtosis imaging of brain white matter alteration in patients with acute mild traumatic brain injury based on the TBSS method
GUO Ran  XIN Ruiqiang  SHI Yijie  ZHONG Jiali  YANG Hongyu  PENG Ruchen 

Cite this article as: GUO R, XIN R Q, SHI Y J, et al. Diffusion kurtosis imaging of brain white matter alteration in patients with acute mild traumatic brain injury based on the TBSS method[J]. Chin J Magn Reson Imaging, 2024, 15(7): 94-98. DOI:10.12015/issn.1674-8034.2024.07.016.


[Abstract] Objective Diffusion kurtosis imaging (DKI) was used to study the white matter microstructure changes in mild traumatic brain injury (mTBI) patients, so as to explore the clinical application value of DKI in mTBI patients.Materials and Methods The clinical and DKI data of 27 mTBI patients who were diagnosed in our hospital and 27 healthy control subjects matched in gender, age, and years of education recruited from January to December 2018 were analyzed. Using the tract-based spatial statistics (TBSS) method to analyze the differences in brain regions and their fractional anisotropy (FA) value, mean kurtosis (MK) value, axial kurtosis (AK) value, radial kurtosis (RK) value, and kurtosis fractional anisotropy (KFA) value between the mTBI patients subjects and the control subjects.Results The FA value of the left superior longitudinal fasciculus (temporal part) was lower in mTBI patients (0.450±0.048) than that in the control subjects (0.480±0.028, t=-2.253, P=0.028 5). The AK value of the forceps major was lower in mTBI patients (0.68±0.05) than that in the control subjects (0.72±0.05, t=-2.407, P=0.019 7). The RK value of the right cingulum (hippocampus) was lower in mTBI patients (0.89±0.15) than that in the control subjects (0.99±0.18, t=-2.044, P=0.0 460). The KFA values of the right anterior thalamic radiation, the right cingulum (cingulate gyrus), the right inferior fronto-occipital fasciculus, the right inferior longitudinal fasciculus, and the right superior longitudinal fasciculus (temporal part) were lower in mTBI patients [(0.49±0.19), (0.50±0.32), (0.48±0.30), (0.49±0.03), and (0.54±0.59)] than that in the control subjects[(0.51±0.13), (0.52±0.20), (0.50±0.02), (0.51±0.26), and (0.57±0.46), t=-2.15, -2.95, -2.37, -2.38, and -2.25, respectively,all P＜0.05]. However, there was no statistically significant difference in MK values between the subjectss (P>0.05).Conclusions The DKI parameter serves as a neuroimaging biomarker for assessing brain white matter alterations in patients with acute mTBI, capable of unveiling minute variations in white matter microstructure.
[Keywords] traumatic brain injury；magnetic resonance imaging；diffusion kurtosis imaging；tract-based spatial statistics；kurtosis fractional anisotropy

GUO Ran   XIN Ruiqiang   SHI Yijie   ZHONG Jiali   YANG Hongyu   PENG Ruchen*  

Department of Radiology, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, China

Corresponding author: PENG R C, E-mail: pengruchen@ccmu.edu.cn

Conflicts of interest   None.

Received  2023-12-16
Accepted  2024-07-12
DOI: 10.12015/issn.1674-8034.2024.07.016
Cite this article as: GUO R, XIN R Q, SHI Y J, et al. Diffusion kurtosis imaging of brain white matter alteration in patients with acute mild traumatic brain injury based on the TBSS method[J]. Chin J Magn Reson Imaging, 2024, 15(7): 94-98. DOI:10.12015/issn.1674-8034.2024.07.016.

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