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• Clinical Article •
Value of dynamic contrast-enhanced MRI in evaluating the microcirculation of extraocular muscle and stage of thyroid-associated ophthalmopathy
PU Xiongying  HU Hao  LU Jinling  WU Qian  ZHOU Jiang  CHEN Huanhuan  WU Feiyun  XU Xiaoquan 

Cite this article as: PU X Y, HU H, LU J L, et al. Value of dynamic contrast-enhanced MRI in evaluating the microcirculation of extraocular muscle and stage of thyroid-associated ophthalmopathy[J]. Chin J Magn Reson Imaging, 2024, 15(7): 99-104. DOI:10.12015/issn.1674-8034.2024.07.017.


[Abstract] Objective To assess the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for staging thyroid-associated ophthalmopathy (TAO).Materials and Methods We prospectively enrolled 56 TAO patients , and divided them into active group (37 patients with 74 eyes) and inactive group (19 patients with 38 eyes). The minimum, mean, and maximum values of semi-quantitative [time to peak (TTP), area under the time-signal intensity curve (AUC), maximum enhancement slope (Slopemax)] and quantitative [volume transfer constant (Ktrans), the rate constant (Kep), fractional volume of the extravascular-extracellular space (Ve)] parameters were calculated and compared between groups. Multivariate logistic regression analysis was applied to identify the independent imaging indicators of active TAO. Receiver operating characteristic (ROC) curve analysis was used to evaluate the performance of the identified significant imaging parameters and their combination.Results Active patients showed significantly higher mean TTP, mean and maximum AUC, mean and maximum Ve than inactive patients (P<0.05). Maximum AUC and mean Ve were found to be independent variables for determining the disease activity (P=0.030, 0.014, respectively). The area under ROC curve of active TAO was 0.689 and 0.673, respectively, using the maximum AUC and the mean Ve values. Combination of two parameters could determine the active TAO with optimal performance (area under the ROC curve 0.731).Conclusions DCE-MRI-derived semi-quantitative and quantitative parameters are all useful for determining the activity of TAO. The model combining maximum AUC and mean Ve can effectively help to stage the patients with TAO.
[Keywords] autoimmune eye disease；thyroid-associated ophthalmopathy；clinical staging；extraocular muscle；dynamic contrast-enhanced；magnetic resonance imaging

PU Xiongying1   HU Hao1   LU Jinling1   WU Qian1   ZHOU Jiang1   CHEN Huanhuan2   WU Feiyun1   XU Xiaoquan1*  

1 Department of Radiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

2 Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

Corresponding author: XU X Q, E-mail: xiaoquanxu_1987@163.com

Conflicts of interest   None.

Received  2024-03-12
Accepted  2024-07-05
DOI: 10.12015/issn.1674-8034.2024.07.017
Cite this article as: PU X Y, HU H, LU J L, et al. Value of dynamic contrast-enhanced MRI in evaluating the microcirculation of extraocular muscle and stage of thyroid-associated ophthalmopathy[J]. Chin J Magn Reson Imaging, 2024, 15(7): 99-104. DOI:10.12015/issn.1674-8034.2024.07.017.

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