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• Clinical Article •
Study on the value of combining intravoxel incoherent motion with apparent diffusion coefficient in the diagnosis of prostate cancer
CHEN Zhaoting  ZOU Yujian  YUAN Zhuobin  WANG Chaoyang  HUANG Xiaolan  ZHANG Kunlin  CHEN Youjun  LIANG Guifeng 

Cite this article as: CHEN Z T, ZOU Y J, YUAN Z B, et al. Study on the value of combining intravoxel incoherent motion with apparent diffusion coefficient in the diagnosis of prostate cancer[J]. Chin J Magn Reson Imaging, 2024, 15(7): 118-123, 142. DOI:10.12015/issn.1674-8034.2024.07.020.


[Abstract] Objective To explore the diagnostic value of combining quantitative parameters of intravoxel incoherent motion (IVIM) with apparent diffusion coefficient (ADC) for prostate cancer (PCa).Materials and Methods Seventy-four cases underwent multiparametric magnetic resonance (mpMRI) prostate examination, including 41 cases of PCa (28 cases in the peripheral zone, 13 cases in the transitional zone) and 33 cases of benign prostatic hyperplasia (BPH). Quantitative parameters including true diffusion coefficient (D), pseudo-diffusion coefficient (D*), perfusion fraction (f), and ADC value were obtained by using a bi-exponential model fitting algorithm. The differences in D value, D* value, f value and ADC value were compared between PCa and prostate hyperplastic nodule with hypointense and hyperintense in T2WI. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic efficacy of combining IVIM quantitative parameters with ADC for PCa. The correlation of each quantitative parameter of IVIM and ADC with the Gleason score was analyzed.Results The ADC, D, and f values of PCa were significantly lower than those of hyperplastic nodule with hypointense and hyperintense in T2WI, with statistically significant differences (P<0.05). D value had the largest area under the curve (AUC) and the highest specificity in distinguishing PCa from prostate hyperplastic nodule with hypointense in T2WI, with statistically significant differences (P<0.05). The combination of ADC, D and f values significantly increased the AUC and sensitivity between PCa and hyperplastic nodule with hypointense in T2WI (0.948, 90.24% respectively). ADC value showed very high AUC, sensitivity and specificity for distinguishing PCa from prostate hyperplastic nodule with hyperintense in T2WI (0.997, 97.65%, 100.00% respectively). There was no significant correlation between ADC value, each quantitative parameter of IVIM and the Gleason score (P=0.068, 0.455, 0.822, 0.297).Conclusions The quantitative parameters of IVIM combined with ADC can obviously improve the differential diagnostic efficacy for PCa and BPH.
[Keywords] prostate cancer；prostate hyperplasia；magnetic resonance imaging；intravoxel incoherent motion；apparent diffusion coefficient；differential diagnosis

CHEN Zhaoting1   ZOU Yujian1*   YUAN Zhuobin1   WANG Chaoyang1   HUANG Xiaolan1   ZHANG Kunlin1   CHEN Youjun2   LIANG Guifeng2  

1 Department of Radiology, the Tenth Affiliated Hospital of Southern Medical University (Dongguan People's Hospital), Dongguan 523059, China

2 Department of Urology, the Tenth Affiliated Hospital of Southern Medical University (Dongguan People's Hospital), Dongguan 523059, China

Corresponding author: ZOU Y J, E-mail: zouyujian@sohu.com

Conflicts of interest   None.

Received  2024-03-15
Accepted  2024-06-11
DOI: 10.12015/issn.1674-8034.2024.07.020
Cite this article as: CHEN Z T, ZOU Y J, YUAN Z B, et al. Study on the value of combining intravoxel incoherent motion with apparent diffusion coefficient in the diagnosis of prostate cancer[J]. Chin J Magn Reson Imaging, 2024, 15(7): 118-123, 142. DOI:10.12015/issn.1674-8034.2024.07.020.

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