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• Clinical Article •
Study on the correlation between infrapatellar fat pad IDEAL-IQ and T2 mapping sequences and the severity of knee osteoarthritis
HAO Tianqi  ZHANG YUAN  WANG Guohua  HUANG Xiaoming  Yang Yaqing  ZHAO Hongfei 

Cite this article as: HAO T Q, ZHANG Y, WANG G H, et al. Study on the correlation between infrapatellar fat pad IDEAL-IQ and T2 mapping sequences and the severity of knee osteoarthritis[J]. Chin J Magn Reson Imaging, 2024, 15(7): 137-142. DOI:10.12015/issn.1674-8034.2024.07.023.


[Abstract] Objective: To investigate the relationship between the fat fraction (FF) and T2 values of the infrapatellar fat pad (IPFP) and the severity of knee osteoarthritis (KOA) in patients.Materials and Methods Prospective recruitment included 99 participants (34 males, 65 females) who underwent knee joint X-ray and MRI on the same day. Participants were categorized into three groups based on knee joint X-ray Kellgren-Lawrence grading (KLG): no KOA group (KLG 0-1), mild KOA group (KLG 2), and severe KOA group (KLG 3-4). The FF and T2 values of the IPFP were measured using 3.0 T MR iteraterative decomposition of water and fat with echo asymmetry and least-squares estimation quantitation (IDEAL-IQ) and T2 mapping techniques, and employed Pearson or Spearman correlation analysis to examine the relationship between FF values, T2 values, and the severity of KOA. The diagnostic performance of FF and T2 values for KOA was evaluated using receiver operating characteristic (ROC) curves.Results As the severity of KOA progressed, the FF of the IPFP decreased correspondingly, and the T2 values increased. There were significant differences in FF and T2 values among the no KOA, severe KOA, and mild KOA groups, with FF values of 73.13%±3.98%, 67.42%±2.25%, and 61.92%±3.24%, and T2 values of 81.04 (79.61, 82.44) ms, 82.72 (81.44, 84.46) ms, and 86.79 (85.32, 89.12) ms, respectively (all P<0.001). The FF values were negatively correlated with KLG (r=-0.779), while the T2 values were positively correlated with KLG (r=0.688). The area under the curve (AUC) for diagnosing the presence of KOA using FF and T2 values was 0.937 and 0.837, with sensitivities of 71.8% and 70.0%, and specificities of 91.7% and 82.1%, respectively.Conclusions Changes in FF and T2 values of the IPFP can to some extent reflect the pathophysiological changes of the IPFP and are related to the severity of KOA, providing new methods for the evaluation of KOA.
[Keywords] knee osteoarthritis；infrapatellar fat pad；magnetic resonance imaging；quantitative detection

HAO Tianqi1, 2   ZHANG YUAN3   WANG Guohua1*   HUANG Xiaoming1   Yang Yaqing1, 2   ZHAO Hongfei1  

1 Department of Radiology, Qingdao Municipal Hospital, Qingdao 266011, China

2 Graduate School, Dalian Medical University, Dalian 116000, China

3 Department of Thoracic Surgery, Qingdao Municipal Hospital, Qingdao 266011, China

Corresponding author: WANG G H, E-mail: wangguohua89@163.com

Conflicts of interest   None.

Received  2024-02-20
Accepted  2024-07-09
DOI: 10.12015/issn.1674-8034.2024.07.023
Cite this article as: HAO T Q, ZHANG Y, WANG G H, et al. Study on the correlation between infrapatellar fat pad IDEAL-IQ and T2 mapping sequences and the severity of knee osteoarthritis[J]. Chin J Magn Reson Imaging, 2024, 15(7): 137-142. DOI:10.12015/issn.1674-8034.2024.07.023.

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