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Progress of quantitative prediction of the pathologic complete response after neoadjuvant chemoradiotherapy for locally advanced rectal cancer with functional MRI
YANG Ao  ZHOU Peng 

Cite this article as: YANG A, ZHOU P. Progress of quantitative prediction of the pathologic complete response after neoadjuvant chemoradiotherapy for locally advanced rectal cancer with functional MRI[J]. Chin J Magn Reson Imaging, 2024, 15(7): 210-215. DOI:10.12015/issn.1674-8034.2024.07.035.


[Abstract] Neoadjuvant chemoradiotherapy (nCRT) could reduce the local recurrence rate and improve the anus-preserving rate in patients with locally advanced rectal cancer (LARC). Some patients can achieve pathologic complete response (pCR) after nCRT, who will be take "watch and wait" strategy, and the patients could be avoid the complications caused by surgery. Functional magnetic resonance imaging (fMRI) can more accurately assess patients' response to nCRT than conventional MRI by reflecting changes in the structure and function of the tumor microenvironment at the cellular level. In this paper, we review the research progress on the quantitative evaluation of pCR after nCRT by diffusion-weighted imaging (DWI) and its derived sequences and perfusion imaging in patients with LARC, compare the advantages and disadvantages of DWI, intravoxel incoherent motion (IVIM), stretched exponential model (SEM), diffusion kurtosis imaging (DKI), dynamic contrast-enhanced MRI (DCE-MRI), and artificial intelligence-based prediction models in the current research, and provide clues and ideas for future research directions, aiming to provide relative reliable quantitative indicators for accurately identifying patients with LARC who achieve pCR.
[Keywords] locally advanced rectal cancer；neoadjuvant chemoradiotherapy；pathologic complete response；functional magnetic resonance imaging；magnetic resonance imaging

YANG Ao1, 2   ZHOU Peng2*  

1 School of Medicine University of Electronic Science and Technology of China, Chengdu 610051, China

2 Department of Radiology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu 610041, China

Corresponding author: ZHOU P, E-mail: penghyzhou@126.com

Conflicts of interest   None.

Received  2024-03-01
Accepted  2024-06-26
DOI: 10.12015/issn.1674-8034.2024.07.035
Cite this article as: YANG A, ZHOU P. Progress of quantitative prediction of the pathologic complete response after neoadjuvant chemoradiotherapy for locally advanced rectal cancer with functional MRI[J]. Chin J Magn Reson Imaging, 2024, 15(7): 210-215. DOI:10.12015/issn.1674-8034.2024.07.035.

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