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• Clinical Article •
A resting-state functional magnetic resonance imaging study of abnormal brain function in patients with Internet gaming disorder
CHEN Jun  ZHANG Yong  NIU Xiaoyu  ZHANG Mengzhe  MA Longyao  CHENG Jingliang 

Cite this article as: CHEN J, ZHANG Y, NIU X Y, et al. A resting-state functional magnetic resonance imaging study of abnormal brain function in patients with Internet gaming disorder[J]. Chin J Magn Reson Imaging, 2024, 15(8): 59-64. DOI:10.12015/issn.1674-8034.2024.08.009.


[Abstract] Objective To explore the changes of local intrinsic brain connectivity in the resting state of Internet gaming disorder (IGD) using a combination of regional homogeneity (ReHo) and functional connectivity (FC).Materials and Methods Resting-state functional magnetic resonance imaging (rs-fMRI) was performed on 44 patients with IGD and 49 healthy controls with matching age, sex, and years of education. The ReHo of the two groups was calculated and compared to detect the changes of local connections in the brain of IGD patients. FC was performed with ReHo abnormal brain regions to obtain changes in the connectivity of different brain regions. The Internet Addiction Test (IAT) was used to assess the severity of Internet gaming disorder. Pearson correlation analysis was used to assess the relationship between brain regions with ReHo alterations and IAT scores.Results In the IGD group, the bilateral medial superior frontal gyrus, bilateral dorsolateral superior frontal gyrus, left auxiliary motor area, and right middle frontal gyrus increased ReHo. Left inferior occipital gyrus, left middle occipital gyrus, left lingual gyrus, left calcarine sulcus cortex, left fusiform gyrus, left superior temporal gyrus, and left cerebellar ReHo are reduced (voxel level P<0.005, mass level P<0.05, Gaussian random field correction). In the IGD group, the functional connectivity of the right dorsolateral superior frontal gyrus and the right superior frontal gyrus, bilateral accessory motor areas, and right precentral gyrus was increased (voxel level P<0.005, mass level P<0.05, Gaussian random field correction). In addition, the ReHo value of the cortex around the left calcarine sulcus cortex was negatively correlated with the IAT score.Conclusions Alterations in local connections in the prefrontal cortex and temporal-occipital cortex may indicate that cognitive control and reward processing and visual and auditory networks in IGD have been affected. In addition, the ReHo value of the cortex around the left calcarine sulcus cortex was negatively correlated with the IAT score, which may provide a new understanding of the neuropathological mechanism of IGD.
[Keywords] Internet gaming disorder；resting-state functional magnetic resonance imaging；magnetic resonance imaging；regional homogeneity；functional connectivity

CHEN Jun   ZHANG Yong*   NIU Xiaoyu   ZHANG Mengzhe   MA Longyao   CHENG Jingliang  

Department of Magnetic Resonance, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450002, China

Corresponding author: ZHANG Y, E-mail: zzuzhangyong2013@163.com

Conflicts of interest   None.

Received  2023-12-19
Accepted  2024-07-30
DOI: 10.12015/issn.1674-8034.2024.08.009
Cite this article as: CHEN J, ZHANG Y, NIU X Y, et al. A resting-state functional magnetic resonance imaging study of abnormal brain function in patients with Internet gaming disorder[J]. Chin J Magn Reson Imaging, 2024, 15(8): 59-64. DOI:10.12015/issn.1674-8034.2024.08.009.

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