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• Clinical Article •
Research on aquaporin magnetic resonance molecular imaging of hippocampal subfields in Alzheimer's disease
SHI Liwei  CHEN Qiuyan  CHEN Tingting  ZHENG Yushan  WU Yaqi  LI Zhaoyang  WEI Dingtai 

Cite this article as: SHI L W, CHEN Q Y, CHEN T T, et al. Research on aquaporin magnetic resonance molecular imaging of hippocampal subfields in Alzheimer's disease[J]. Chin J Magn Reson Imaging, 2024, 15(8): 65-72, 83. DOI:10.12015/issn.1674-8034.2024.08.010.


[Abstract] Objective This study applied aquaporin magnetic resonance molecular imaging (AQP-MRMI) technology to quantitatively analyze the hippocampal subfield, aiming to explore the application value of AQP-MRMI technology in the diagnosis of Alzheimer's disease (AD).Materials and Methods A total of 59 subjects were included in this study, including 16 subjects in the AD group and 22 subjects in the mild cognitive impairment (MCI) group, and 21 subjects in the normal control (NC) group. Aquaporin apparent diffusion coefficient (AQP-ADC) values were measured and recorded to analyze whether the differences in AQP-ADC values among the three groups were statistically significant, and correlation analysis was conducted with cognitive scores. The receiver operating characteristic (ROC) curve of AQP-ADC values was drawn, and the area under the sensitivity and specificity curve and diagnostic threshold were analyzed.Results There were statistical differences in AQP-ADC values of all hippocampal subfields except the right entorhinal cortex among the three groups (P<0.05). Compared with the NC group, the MCI group only showed increased AQP-ADC value of cornu ammonis-1 (CA1) on the left side (P<0.05), the AD group showed increased AQP-ADC values of bilateral dentate gyrus (DG) -CA4, bilateral CA1-3, bilateral para-hippocampus and left entorhinal cortex (P<0.05); compared with the MCI group, the AQP-ADC values of bilateral DG-CA4, bilateral CA1-3, right subiculum and right para-hippocampus in AD group were increased (P<0.05). The AQP-ADC values of all hippocampal subfields were negatively correlated with the total score of Mini-Mental State Examination (MMSE), except for the right subiculum, and the left DG-CA4 (r=-0.607, P<0.001) and the left CA1-3 (r=-0.633, P<0.001) showed a significant correlation with MMSE. The ROC curve analysis showed that AQP-ADC values of multiple hippocampal subfields region of interest (ROI) could be used to identify NC and AD, MCI, among which the AQP-ADC values of left DG-CA4 and left CA1-3 had the largest area under the curve (AUC=0.905, 0.940) between NC and AD group with high sensitivity and specificity.Conclusions In this study, AQP-ADC values in several hippocampal subfields were correlated with cognitive function, especially the left DG-CA4 and left CA1-3 subregions, which helped evaluate the severity of cognitive impairment and had superior diagnostic efficacy in distinguishing AD from cognitively normal elderly people, and could be used as biomarkers for the detection of AD. The AQP-ADC values of the left CA1 may be expected to be a potential biomarker for early AD. AQP-MRMI, as an emerging aquaporin molecular imaging technology, can reflect the pathophysiological changes of AD, and provide more information for the diagnosis, treatment, and prognosis assessment of AD at the molecular level.
[Keywords] Alzheimer's disease；mild cognitive impairment；aquaporin magnetic resonance molecular imaging；magnetic resonance imaging；hippocampal subfields

SHI Liwei1, 2, 3   CHEN Qiuyan2, 3   CHEN Tingting2   ZHENG Yushan1   WU Yaqi1   LI Zhaoyang1   WEI Dingtai1, 2, 3*  

1 The School of Clinical Medicine, Fujian Medical University, Fuzhou 350000, China

2 Department of Imaging, Ningde Hospital Affiliated to Ningde Normal University, Ningde 352100, China

3 Functional and Molecular Imaging Laboratory for Cerebral Vascular Diseases, Ningde Hospital Affiliated to Ningde Normal University, Ningde 352100, China

Corresponding author: WEI D T, E-mail: wdtai83@163.com

Conflicts of interest   None.

Received  2023-12-30
Accepted  2024-07-15
DOI: 10.12015/issn.1674-8034.2024.08.010
Cite this article as: SHI L W, CHEN Q Y, CHEN T T, et al. Research on aquaporin magnetic resonance molecular imaging of hippocampal subfields in Alzheimer's disease[J]. Chin J Magn Reson Imaging, 2024, 15(8): 65-72, 83. DOI:10.12015/issn.1674-8034.2024.08.010.

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